1. Gene
  2. SH3RF2 - SH3 domain containing ring finger 2 Gene

SH3RF2 - SH3 domain containing ring finger 2 Gene

中文名称:含 SH3 结构域的无名指 2

种属: Homo sapiens

同用名: HEPP1; POSHER; RNF158; PPP1R39

基因 ID: 153769 | 基因类型: protein coding

关于 SH3RF2

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:145,936,578-146,081,773 (from NCBI)

This gene has 7 transcripts (splice variants), 163 orthologues and 12 paralogues. Biased expression in skin (RPKM 22.7), testis (RPKM 19.4) and 12 other tissues.

功能概要

启用蛋白磷酸酶 1 结合活性和泛素蛋白连接酶活性。参与多个过程,包括 JNK 级联的正调控;蛋白质自身泛素化;和调节细胞蛋白质代谢过程。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein Phosphatase 1 binding activity and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of cellular protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF2 基因产物(1)

mRNA Protein Name
NM_152550.4 NP_689763.4 E3 ubiquitin-protein ligase SH3RF2

SH3RF2 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 52)

SH3_2

SH3_2: Variant SH3 domain (129 - 182)

SH3_9

SH3_9: Variant SH3 domain (194 - 248)

SH3_9

SH3_9: Variant SH3 domain (387 - 436)

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  • 729 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase SH3RF2

POSH-eliminating RING protein

SH3RF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
31515488
种属内
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 EFS Homo sapiens O43281-2
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
种属内
SH3RF2 Q8TEC5 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 BAG4 Homo sapiens O95429
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Pull Down
19389623
种属内
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Y2H
22321011
种属内
SH3RF2 Q8TEC5 PPP1CA Homo sapiens P62136
Far-WB
19389623
种属内
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
种属内
SH3RF2 Q8TEC5 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
种属内
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
种属内
SH3RF2 Q8TEC5 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ureter Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Ureter

Ureteral Urothelial Cell Carcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SH3RF2 MGD MGI:2444628
Macaca mulatta SH3RF2 VGNC VGNC:77315
Canis familiaris SH3RF2 VGNC VGNC:46133
Felis catus SH3RF2 VGNC VGNC:65114
Rattus norvegicus SH3RF2 RGD RGD:1308415
Bos taurus SH3RF2 VGNC VGNC:34580