PSMC3 - proteasome 26S subunit, ATPase 3 Gene

中文名称：蛋白酶体 26S 亚基，ATPase 3

种属: Homo sapiens

同用名: RPT5; TBP1; DCIDP

基因 ID: 5702 | 基因类型: protein coding

关于 PSMC3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,418,775-47,426,439 (from NCBI)

This gene has 13 transcripts (splice variants), 220 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 35.4), brain (RPKM 35.2) and 25 other tissues.

功能概要

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码一个 ATP 酶亚基，它是具有伴侣样活性的 ATP 酶三 A 家族的成员。该亚基可能与 PSMC2 竞争结合 HIV tat 蛋白，以调节病毒蛋白与转录复合物之间的相互作用。已在 9 号染色体上鉴定出假基因。[RefSeq 提供，2008 年 7 月]

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

PSMC3 基因产物(1)

mRNA	Protein	Name
NM_002804.5	NP_002795.2	26S proteasome regulatory subunit 6A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16713569	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in modulation by host of viral transcription	IDA IDA: 通过直接分析推断	2194290	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19853614	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	2194290	GOA
part of proteasome complex	IDA IDA: 通过直接分析推断	9464850	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMC3 蛋白结构

AAA

0
100
200
300
400
439 a.a.

蛋白主名

其他名称

26S proteasome regulatory subunit 6A

26S protease regulatory subunit 6A

PSMC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Array	25416956
Intra	PSMC3	P17980	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	31515488
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	25416956
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	32296183
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Cataract, Impaired Intellectual Development, And Polyneuropathy

DCIDP

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Polyneuropathy

Polyneuropathies

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11312	PSMC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11313	PSMC3IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PSMC3	MGD	MGI:1098754
Rattus norvegicus	PSMC3	RGD	RGD:61905
Macaca mulatta	PSMC3	VGNC	VGNC:101385
Felis catus	PSMC3	VGNC	VGNC:69113
Bos taurus	PSMC3	VGNC	VGNC:33456

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4