PSMD9 - proteasome 26S subunit, non-ATPase 9 Gene

中文名称：蛋白酶体 26S 亚基，非 ATPase 9

种属: Homo sapiens

同用名: p27; Rpn4

关于 PSMD9

功能概要

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码 19S 调节器的非 ATPase 亚基。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2012 年 5 月]

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]