2. Gene
  3. TRIM39 - tripartite motif containing 39 Gene

TRIM39 - tripartite motif containing 39 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 39

种属: Homo sapiens

同用名: TFP; RNF23; TRIM39B

基因 ID: 56658 | 基因类型: protein coding

关于 TRIM39

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,326,469-30,343,729 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 128 orthologues and 80 paralogues. Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。这种蛋白质的功能尚未确定。该基因位于 6 号染色体上的主要组织相容性复合体 I 类区域。交替剪接导致编码不同亚型的两个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM39 基因产物(5)

mRNA Protein Name
NM_001369521.2 NP_001356450.1 E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369522.1 NP_001356451.1 E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369523.1 NP_001356452.1 E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_021253.4 NP_067076.2 E3 ubiquitin-protein ligase TRIM39 isoform 1
NM_172016.2 NP_742013.1 E3 ubiquitin-protein ligase TRIM39 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
23213251 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
26363554 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23213251 GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
19100260 GOA
involved in positive regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
19100260 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
23213251 GOA
involved in regulation of cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
23213251 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
19100260 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
19100260 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23213251 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM39 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (29 - 69)

zf-B_box

zf-B_box: B-box zinc finger (103 - 143)

PRY

PRY: SPRY-associated domain (339 - 388)

SPRY

SPRY: SPRY domain (390 - 499)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 518 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM39

RING-type E3 ubiquitin transferase TRIM39

TRIM39 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRIM39 Q9HCM9 SMCO3 Homo sapiens A2RU48
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 SMCO3 Homo sapiens A2RU48
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 SMCO3 Homo sapiens A2RU48
Y2H Array
25416956
Intra TRIM39 Q9HCM9 DC-UbP Homo sapiens B2R886
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 DC-UbP Homo sapiens B2R886
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 DC-UbP Homo sapiens B2R886
Y2H Array
25416956
Intra TRIM39 Q9HCM9 EPHB6 Homo sapiens O15197-2
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 EPHB6 Homo sapiens O15197-2
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 EIF4A2 Homo sapiens Q14240-2
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 EIF4A2 Homo sapiens Q14240-2
Y2H Array
25416956
Intra TRIM39 Q9HCM9 DIP2A Homo sapiens Q14689-6
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 DIP2A Homo sapiens Q14689-6
Y2H Array
25416956
Intra TRIM39 Q9HCM9 RECK Homo sapiens Q6P9E2
Y2H Array
25416956
Intra TRIM39 Q9HCM9 WDFY3 Homo sapiens Q8IZQ1-2
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 LXN Homo sapiens Q9BS40
Y2H Array
25416956
Intra TRIM39 Q9HCM9 LXN Homo sapiens Q9BS40
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 UBXN1 Homo sapiens Q04323
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 UBXN6 Homo sapiens Q9BZV1
Y2H Array
31515488
Intra TRIM39 Q9HCM9 UBXN6 Homo sapiens Q9BZV1
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 UBXN6 Homo sapiens Q9BZV1
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBXN6 Homo sapiens Q9BZV1
Y2H Array
29892012
Intra TRIM39 Q9HCM9 UBE2E2 Homo sapiens Q96LR5
Y2H Array
19549727
Intra TRIM39 Q9HCM9 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 UBE2E2 Homo sapiens Q96LR5
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBE2E2 Homo sapiens Q96LR5
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 ZKSCAN4 Homo sapiens Q969J2
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 ZNF26 Homo sapiens P17031
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 ZNF26 Homo sapiens P17031
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 ZNF26 Homo sapiens P17031
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBE2D3 Homo sapiens P61077
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBE2E3 Homo sapiens Q969T4
Y2H Array
31515488
Intra TRIM39 Q9HCM9 UBE2E3 Homo sapiens Q969T4
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 UBE2E3 Homo sapiens Q969T4
Y2H Array
19549727
Intra TRIM39 Q9HCM9 UBE2E3 Homo sapiens Q969T4
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 PSMA6 Homo sapiens P60900
Y2H Array
25416956
Intra TRIM39 Q9HCM9 PSMA6 Homo sapiens P60900
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 PSMA6 Homo sapiens P60900
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 MED18 Homo sapiens Q9BUE0
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 MED18 Homo sapiens Q9BUE0
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 CCNC Homo sapiens P24863
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 UBE2K Homo sapiens P61086
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 EIF4A2 Homo sapiens Q14240
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 EIF4A2 Homo sapiens Q14240
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 TRIM17 Homo sapiens Q9Y577
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 TRIM17 Homo sapiens Q9Y577
Y2H Array
29892012
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Pull Down
16189514
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Y2H Array
22493164
Intra TRIM39 Q9HCM9 TRIM17 Homo sapiens Q9Y577
Y2H Array
31515488
Intra TRIM39 Q9HCM9 UBE2D1 Homo sapiens P51668
Y2H
21516116
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Y2H Array
25416956
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Y2H
21516116
Intra TRIM39 Q9HCM9 TRIM17 Homo sapiens Q9Y577
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 UBE2D1 Homo sapiens P51668
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Y2H Pooling
16189514
Intra TRIM39 Q9HCM9 TRIM39 Homo sapiens Q9HCM9
Anti Tag CoIP
22493164
Intra TRIM39 Q9HCM9 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra TRIM39 Q9HCM9 TRIM17 Homo sapiens Q9Y577
Y2H Array
22493164
Intra TRIM39 Q9HCM9 UBE2D1 Homo sapiens P51668
Y2H Array
25416956
Intra TRIM39 Q9HCM9 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 DCUN1D1 Homo sapiens Q96GG9
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 DCUN1D1 Homo sapiens Q96GG9
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 POLI Homo sapiens Q9UNA4
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 PRPF3 Homo sapiens O43395
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 PRPF3 Homo sapiens O43395
Y2H Array
25416956
Intra TRIM39 Q9HCM9 PRPF3 Homo sapiens O43395
Y2H
21516116
Intra TRIM39 Q9HCM9 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBTD1 Homo sapiens Q9HAC8
Y2H Pooling
16189514
Intra TRIM39 Q9HCM9 UBTD1 Homo sapiens Q9HAC8
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 UBAC1 Homo sapiens Q9BSL1
Y2H Array
25416956
Intra TRIM39 Q9HCM9 UBAC1 Homo sapiens Q9BSL1
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 PSMD9 Homo sapiens O00233
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 PSMD9 Homo sapiens O00233
Y2H Array
25416956
Intra TRIM39 Q9HCM9 PSMD9 Homo sapiens O00233
Y2H
21516116
Intra TRIM39 Q9HCM9 TRIM21 Homo sapiens P19474
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 TRIM21 Homo sapiens P19474
Y2H Array
22493164
Intra TRIM39 Q9HCM9 TTC32 Homo sapiens Q5I0X7
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 a8k2r3_human Homo sapiens A8K2R3
Validated Y2H
25416956
Intra TRIM39 Q9HCM9 a8k2r3_human Homo sapiens A8K2R3
Y2H Prey Pooling
25416956
Intra TRIM39 Q9HCM9 a8k2r3_human Homo sapiens A8K2R3
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15043 TRIM39 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRIM39 MGD MGI:1890659
Rattus norvegicus TRIM39 RGD RGD:1303115
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