1. Gene
  2. MED18 - mediator complex subunit 18 Gene

MED18 - mediator complex subunit 18 Gene

中文名称:调解复合体亚基 18

种属: Homo sapiens

同用名: SRB5; p28b

基因 ID: 54797 | 基因类型: protein coding

关于 MED18

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,329,040-28,335,965 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 197 orthologues. Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues.

功能概要

MED18 是 Mediator 复合体的一个组成部分,它是通过 RNA 聚合酶 II 激活转录的 DNA 结合因子的共激活因子 (Sato 等人,2003 [PubMed 12584197]) 。[OMIM 提供,2008 年 10 月]

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED18 基因产物(2)

mRNA Protein Name
NM_001127350.2 NP_001120822.1 mediator of RNA polymerase II transcription subunit 18
NM_017638.3 NP_060108.2 mediator of RNA polymerase II transcription subunit 18
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12584197 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of core mediator complex IPI
IPI: 通过物理相互作用推断
24882805 GOA
part of mediator complex IDA
IDA: 通过直接分析推断
14638676 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24882805 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MED18 蛋白结构

Med18

Med18: Med18 protein (19 - 77)

Med18

Med18: Med18 protein (80 - 205)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 18

TRAP/mediator complex subunit p28b

MED18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MED18 Q9BUE0 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
25416956
Intra MED18 Q9BUE0 CAMK2B Homo sapiens Q13554
Y2H Prey Pooling
25416956
Intra MED18 Q9BUE0 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra MED18 Q9BUE0 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra MED18 Q9BUE0 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra MED18 Q9BUE0 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra MED18 Q9BUE0 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra MED18 Q9BUE0 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
28514442
Intra MED18 Q9BUE0 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
35271311
Intra MED18 Q9BUE0 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
33961781
Intra MED18 Q9BUE0 MED17 Homo sapiens Q9NVC6
TAP
24981860
Intra MED18 Q9BUE0 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
24882805
Intra MED18 Q9BUE0 MED6 Homo sapiens O75586
Anti Tag CoIP
33961781
Intra MED18 Q9BUE0 MED6 Homo sapiens O75586
TAP
24981860
Intra MED18 Q9BUE0 MED6 Homo sapiens O75586
Anti Tag CoIP
28514442
Intra MED18 Q9BUE0 MED6 Homo sapiens O75586
Anti Tag CoIP
24882805
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Complementation
32296183
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Validated Y2H
25416956
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Anti Tag CoIP
28514442
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Validated Y2H
32296183
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Anti Tag CoIP
33961781
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
MAPPIT
32296183
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Y2H Array
31515488
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
MAPPIT
25416956
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Anti Tag CoIP
25416956
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Y2H Prey Pooling
32296183
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Anti Tag CoIP
35271311
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Y2H Array
25416956
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
Y2H Array
32296183
Intra MED18 Q9BUE0 MED20 Homo sapiens Q9H944
TAP
24981860
Intra MED18 Q9BUE0 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
33961781
Intra MED18 Q9BUE0 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
28514442
Intra MED18 Q9BUE0 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
35271311
Intra MED18 Q9BUE0 MED22 Homo sapiens Q15528
Anti Tag CoIP
35271311
Intra MED18 Q9BUE0 MED22 Homo sapiens Q15528
TAP
24981860
Intra MED18 Q9BUE0 MED22 Homo sapiens Q15528
Anti Tag CoIP
33961781
Intra MED18 Q9BUE0 MED22 Homo sapiens Q15528
Anti Tag CoIP
24882805
Cross MED18 Q9BUE0 Med20 Mus musculus Q9R0X0
Anti Tag CoIP
12584197
Intra MED18 Q9BUE0 TRIM39 Homo sapiens Q9HCM9
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus MED18 VGNC VGNC:31355
Macaca mulatta MED18 VGNC VGNC:74587
Mus musculus MED18 MGD MGI:1914469
Canis familiaris MED18 VGNC VGNC:43127
Rattus norvegicus MED18 RGD RGD:1592757