MED20 - mediator complex subunit 20 Gene

中文名称：介体复合体亚基 20

种属: Homo sapiens

同用名: SRB2; TRFP; PRO0213

关于 MED20

功能概要

该基因编码介体复合体 (也称为 TRAP、SMCC、DRIP 或 ARC) 的一个组分，这是一种转录共激活因子复合体，被认为是几乎所有基因表达所必需的。介体复合物由转录激活因子或核受体募集，通过与 RNA 聚合酶 II 相互作用并促进转录前起始复合物的形成来诱导基因表达。该基因的突变与一种新型的婴儿期神经退行性运动障碍有关。已经鉴定出可变剪接的转录物变体。[RefSeq 提供，2015 年 3 月]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]