UBXN6 - UBX domain protein 6 Gene

中文名称：UBX 结构域蛋白 6

种属: Homo sapiens

同用名: UBXD1; UBXDC2

基因 ID: 80700 | 基因类型: protein coding

关于 UBXN6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,445,006-4,457,879 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.0), kidney (RPKM 36.6) and 25 other tissues.

功能概要

参与 ERAD 通路；通过多泡体分选途径将核内体转运至溶酶体；和巨自噬。位于细胞器和细胞质的边界膜上。是膜的外在成分。内体和含蛋白质复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Is extrinsic component of membrane. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN6 基因产物(2)

mRNA	Protein	Name
NM_001171091.2	NP_001164562.1	UBX domain-containing protein 6 isoform 2
NM_025241.3	NP_079517.1	UBX domain-containing protein 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18656546	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	19275885	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: 通过突变表型推断	21822278	GOA
involved in macroautophagy	IMP IMP: 通过突变表型推断	27753622	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	27753622	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19275885	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	21822278	GOA
located in endosome	IDA IDA: 通过直接分析推断	26475856	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	21822278	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	21822278	GOA
located in membrane	IDA IDA: 通过直接分析推断	19275885	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	21822278	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBXN6 蛋白结构

PUB

UBX

0
100
200
300
400
441 a.a.

蛋白主名

其他名称

UBX domain-containing protein 6

CTB-50L17.16

UBXN6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Validated Y2H	25416956
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Array	25416956
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Prey Pooling	25416956
种属内	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
种属内	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Anti Tag CoIP	33961781
种属内	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Bait CoIP	18656546
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Validated Y2H	32814053
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	BRET	29997244
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Array	32814053
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Pull Down	18656546
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Lumier	29997244
种属内	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
种属内	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
种属内	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	31515488

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

Ibmpfd1	Msp1
Multisystem Proteinopathy 1

Multisystem Proteinopathy

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15398	UBXN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	UBXN6	VGNC	VGNC:36628
Macaca mulatta	UBXN6	VGNC	VGNC:78971
Canis familiaris	UBXN6	VGNC	VGNC:48101
Rattus norvegicus	UBXN6	RGD	RGD:1590866
Felis catus	UBXN6	VGNC	VGNC:80752
Mus musculus	UBXN6	MGD	MGI:1913780

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBXN6 - UBX domain protein 6 Gene

关于 UBXN6

功能概要

UBXN6 基因产物(2)

UBXN6 蛋白结构

UBXN6 蛋白互作信息

关联疾病

直系同源

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UBXN6 - UBX domain protein 6 Gene

关于 UBXN6

功能概要

UBXN6 基因产物(2)

UBXN6 蛋白结构

UBXN6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

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Q

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