PLEKHB2 - pleckstrin homology domain containing B2 Gene

中文名称：含 pleckstrin 同源结构域 B2

种属: Homo sapiens

同用名: EVT2

基因 ID: 55041 | 基因类型: protein coding

关于 PLEKHB2

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:131,105,336-131,149,845 (from NCBI)

This gene has 12 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 52.2), brain (RPKM 41.1) and 24 other tissues.

功能概要

启用磷脂酰肌醇-3,4,5-三磷酸结合活性。预计参与细胞分化的调节。预测定位于循环内体膜。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHB2 基因产物(13)

mRNA	Protein	Name
NM_001100623.2	NP_001094093.1	pleckstrin homology domain-containing family B member 2 isoform 3
NM_001267062.2	NP_001253991.1	pleckstrin homology domain-containing family B member 2 isoform 4
NM_001267063.2	NP_001253992.1	pleckstrin homology domain-containing family B member 2 isoform 5
NM_001267064.2	NP_001253993.1	pleckstrin homology domain-containing family B member 2 isoform 6
NM_001267065.2	NP_001253994.1	pleckstrin homology domain-containing family B member 2 isoform 7
NM_001267066.2	NP_001253995.1	pleckstrin homology domain-containing family B member 2 isoform 8
NM_001267067.2	NP_001253996.1	pleckstrin homology domain-containing family B member 2 isoform 9
NM_001267068.2	NP_001253997.1	pleckstrin homology domain-containing family B member 2 isoform 10
NM_001309448.2	NP_001296377.1	pleckstrin homology domain-containing family B member 2 isoform 11
NM_001309450.2	NP_001296379.1	pleckstrin homology domain-containing family B member 2 isoform 12
NM_001309451.2	NP_001296380.1	pleckstrin homology domain-containing family B member 2 isoform 13
NM_001309452.2	NP_001296381.1	pleckstrin homology domain-containing family B member 2 isoform 11
NM_017958.3	NP_060428.2	pleckstrin homology domain-containing family B member 2 isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: 通过直接分析推断	11001876	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLEKHB2 蛋白结构

0
100
200
222 a.a.

蛋白主名

其他名称

pleckstrin homology domain-containing family B member 2

PH domain-containing family B member 2

PLEKHB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	RPS27A	Homo sapiens	P62979	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	RPS27A	Homo sapiens	P62979	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	BHLHE40	Homo sapiens	O14503	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	EPN1	Homo sapiens	Q9Y6I3	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	HEY1	Homo sapiens	Q9Y5J3	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	DCUN1D1	Homo sapiens	Q96GG9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	OTUB2	Homo sapiens	Q96DC9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	HEYL	Homo sapiens	Q9NQ87	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypogonadotropic Hypogonadism 4 With Or Without Anosmia

HH4	Kallmann Syndrome 4
Kal4	Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia

Articulation Disorder

Phonological Disorder	Articulation Disorders
Articulation Impairment	Speech Sound Disorders

Vertebral Artery Insufficiency

Vertebral Artery Syndrome

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Speech Disorder

Speech Disorders

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Specific Language Impairment

Language Impairment, Specific

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10686	PLEKHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PLEKHB2	RGD	RGD:1310954
Canis familiaris	PLEKHB2	VGNC	VGNC:44673
Mus musculus	PLEKHB2	MGD	MGI:2385825
Felis catus	PLEKHB2	VGNC	VGNC:64222
Bos taurus	PLEKHB2	VGNC	VGNC:33010

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