UBA52 - ubiquitin A-52 residue ribosomal protein fusion product 1 Gene

中文名称：泛素 A-52 残基核糖体蛋白融合产物 1

种属: Homo sapiens

同用名: L40; CEP52; RPL40; HUBCEP52

关于 UBA52

功能概要

泛素是一种高度保守的细胞核和细胞质蛋白，在靶向细胞蛋白以被 26S 蛋白体降解方面起着重要作用。它还参与染色质结构的维持、基因表达的调节和应激反应。泛素被合成为前体蛋白，由多聚泛素链或与无关蛋白质融合的单个泛素部分组成。该基因编码一种融合蛋白，由 N 端的泛素和 C 端的核糖体蛋白 L40 组成，即 C 端延伸蛋白 (CEP) 。源自该基因的多个加工假基因存在于基因组中。[RefSeq 提供，2008 年 7 月]

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]