2. Gene
  3. CDA - cytidine deaminase Gene

CDA - cytidine deaminase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胞苷脱氨酶

种属: Homo sapiens

同用名: CDD

基因 ID: 978 | 基因类型: protein coding

关于 CDA

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,589,097-20,618,903 (from NCBI)

This gene has 2 transcripts (splice variants) and 239 orthologues. Biased expression in bone marrow (RPKM 57.6), esophagus (RPKM 22.6) and 8 other tissues.

功能概要

该基因编码一种参与嘧啶回收的酶。编码的蛋白质形成同源四聚体，催化胞苷和脱氧胞苷分别不可逆水解脱氨为尿苷和脱氧尿苷。它是负责维持细胞嘧啶池的几种脱氨酶之一。该基因的突变与对用于治疗某些儿童白血病的胞嘧啶核苷类似物胞嘧啶阿糖苷的敏感性降低有关。[RefSeq 提供，2008 年 7 月]

This gene encodes an Enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

CDA 基因产物(1)

mRNA Protein Name
NM_001785.3 NP_001776.1 cytidine deaminase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytidine deaminase activity IDA
IDA: 通过直接分析推断
7923172 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9596658 GOA
enables nucleoside binding IDA
IDA: 通过直接分析推断
15689149 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15689149 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
15689149 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytidine deamination IDA
IDA: 通过直接分析推断
9596658 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
9596658 GOA
involved in negative regulation of nucleotide metabolic process IDA
IDA: 通过直接分析推断
9596658 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
9596658 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDA 蛋白结构

dCMP_cyt_deam_1

dCMP_cyt_deam_1: Cytidine and deoxycytidylate deaminase zinc-binding region (16 - 116)

  • 0
  • 100
  • 146 a.a.
蛋白主名 其他名称

cytidine deaminase

cytidine aminohydrolase

CDA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDA P32320 PTGER3 Homo sapiens P43115-12
Y2H Prey Pooling
25416956
Intra CDA P32320 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra CDA P32320 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra CDA P32320 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra CDA P32320 FOXN1 Homo sapiens O15353
Y2H Prey Pooling
32296183
Intra CDA P32320 FOXN1 Homo sapiens O15353
Y2H Array
32296183
Intra CDA P32320 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra CDA P32320 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra CDA P32320 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra CDA P32320 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra CDA P32320 ARRDC3 Homo sapiens Q96B67
Validated Y2H
32296183
Intra CDA P32320 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra CDA P32320 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra CDA P32320 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra CDA P32320 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
25416956
Intra CDA P32320 ADAT3 Homo sapiens Q96EY9
Validated Y2H
32296183
Intra CDA P32320 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra CDA P32320 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra CDA P32320 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra CDA P32320 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra CDA P32320 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra CDA P32320 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25910212
Intra CDA P32320 LNX1 Homo sapiens Q8TBB1
Y2H Array
25910212
Intra CDA P32320 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra CDA P32320 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra CDA P32320 LNX1 Homo sapiens Q8TBB1
Y2H Bait-Prey Pool
25910212
Intra CDA P32320 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Intra CDA P32320 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra CDA P32320 NTAQ1 Homo sapiens Q96HA8
Y2H Prey Pooling
25416956
Intra CDA P32320 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra CDA P32320 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra CDA P32320 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra CDA P32320 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra CDA P32320 ZBTB24 Homo sapiens O43167
Validated Y2H
25416956
Intra CDA P32320 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra CDA P32320 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
25416956
Intra CDA P32320 FNDC11 Homo sapiens Q9BVV2
Y2H Prey Pooling
25416956
Intra CDA P32320 FNDC11 Homo sapiens Q9BVV2
Validated Y2H
32296183
Intra CDA P32320 FNDC11 Homo sapiens Q9BVV2
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Leukemia

Stem Cell Leukaemia

Stem Cell Leukemia

Acute Leukemias

Acute Undifferentiated Leukemia

Undifferentiated Leukemia

Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

Blast Cell Leukaemia

Blast Leukaemia

Blastic Leukaemia

Undifferentiated Leukaemia
Immunodeficiency With Hyper-Igm, Type 2

HIGM2

Hyper-Igm Syndrome Type 2

Hyper-Igm Syndrome 2

Immunodeficiency With Hyper-Igm Type 2

Activation-Induced Cytidine Deaminase Deficiency

Aid Deficiency

Immunodeficiency With Hyper Igm Type 2

Hyper Igm Syndrome 2

Immunodeficiency With Hyper-Igm 2

Hyper-Igm Immunodeficiency Type 2

Immunodeficiency, With Hyper Igm, Type 2

Hyper-Igm Immunodeficiency Syndrome, Type 2
Hematologic Cancer

Hematologic Neoplasm

Hematologic Neoplasms

Hematologic Malignancies

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13599 Cladribine 99.97% 是
HY-109081 Cedazuridine Inhibitor ≥98.0% 否
HY-109081A Cedazuridine hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-12885A 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt Activator 99.91% Phase 2
HY-12885B 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Activator 99.89% Phase 2
HY-15345 Tetrahydrouridine dihydrate Inhibitor 99.86% Phase 2
HY-12885 2’3’-c-di-AM(PS)2 (Rp,Rp) Activator 99.85% Phase 2
HY-15345A Tetrahydrouridine Inhibitor 99.86% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12885C 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt 98.82% 否
HY-15345AS Tetrahydrouridine-d3 / 否
HY-E70023 Sphingolipid ceramide N-deacylase (SCDase) / 否
HY-N10584 Malacidin A Inhibitor / 否
HY-RS02282 CDA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CDA VGNC VGNC:38983
Bos taurus CDA VGNC VGNC:27055
Mus musculus CDA MGD MGI:1919519
Felis catus CDA VGNC VGNC:80163
Rattus norvegicus CDA RGD RGD:1311101
Macaca mulatta CDA VGNC VGNC:106338
Others CDA NCBI
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