2. Immunology/Inflammation
  3. STING
  4. 2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt)

2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt)  (Synonyms: ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt)

目录号: HY-12885A 纯度: 99.43%
COA 产品使用指南

摩尔计算器

2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。

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2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) Chemical Structure

2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) Chemical Structure

CAS No. : 1638750-95-4

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3300
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of 2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt):

2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 53 篇科研文献

RT-PCR

    2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) purchased from MCE. Usage Cited in: Nat Commun. 2023 Mar 13;14(1):1390.  [Abstract]

    ADU-S100 (10 μM; 48 h; labeled as STING) enhances type I interferon gene expression in human dendritic cells (DCs).

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).

    IC50 & Target

    STING[1]
    体外研究
    (In Vitro)

    2’3’-c-di-AM(PS)2 (Rp,Rp) shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTINGREF and hSTINGQ alleles. 2’3’-c-di-AM(PS)2 (Rp,Rp) induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. 2’3’-c-di-AM(PS)2 (Rp,Rp) is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). 2’3’-c-di-AM(PS)2 (Rp,Rp) induces significantly higher levels of IFN-α when compared to ML cGAMP[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) 相关抗体:
    体内研究
    (In Vivo)

    2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    734.51

    Formula

    C20H22N10Na2O10P2S2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (136.15 mM; 超声助溶 (<60°C))

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.3615 mL 6.8073 mL 13.6145 mL
    5 mM 0.2723 mL 1.3615 mL 2.7229 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: ≥ 25 mg/mL (34.04 mM); 澄清溶液

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.91%

    COA (195 KB) HNMR (250 KB) CNMR (196 KB) LCMS (94 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    Cryopreserved hPBMCs are thawed and 1×106 cells per well are plated in a 96 well plate in RPMI media supplemented with 10% FBS, 1% non-essential amino acids, 1% penicillin/streptomycin, L-glutamine, 10 mM HEPES buffer, 1 mM Sodium Pyruvate, 0.055 mM β-ME at 37°C with 5% CO2. Cells are stimulated with 10 μM ADU-S100 or ML cGAMP for 6 hours and supernatants are harvested. Supernatants are diluted 1:2 and assayed for IFN-α protein using Cytometric Bead Array (CBA) Human Flex Set. Data is collected using a FACSVerse cytometer and analyzed by FCAP Array Software[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Mice[1]
    WT C57BL/6 mice are inoculated with 5×104 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 mice receive three IT doses of either ML RR-S2 CDG (25 μg), ADU-S100 (50 μg), or HBSS as control. WT C57BL/6 mice are inoculated with 5×104 B16.F10 cells in the left flank (n=5). When tumor volumes are 100 mm3 they received three IT doses of ADU-S100 at 5, 25, 50 or 100 μg or HBSS as control. WT C57BL/6 mice are inoculated with 5×104 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 they receive three IT doses of 100 μg ADU-S100 or HBSS as control. Treatments are administered on days 13, 17 and 20 and tumor measurements are taken twice weekly. Results are shown as percent survival by Log-rank (Mantel-Cox) test (A and C)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3615 mL 6.8073 mL 13.6145 mL 34.0363 mL
    5 mM 0.2723 mL 1.3615 mL 2.7229 mL 6.8073 mL
    10 mM 0.1361 mL 0.6807 mL 1.3615 mL 3.4036 mL
    15 mM 0.0908 mL 0.4538 mL 0.9076 mL 2.2691 mL
    20 mM 0.0681 mL 0.3404 mL 0.6807 mL 1.7018 mL
    25 mM 0.0545 mL 0.2723 mL 0.5446 mL 1.3615 mL
    30 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1345 mL
    40 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
    50 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6807 mL
    60 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.5673 mL
    80 mM 0.0170 mL 0.0851 mL 0.1702 mL 0.4255 mL
    100 mM 0.0136 mL 0.0681 mL 0.1361 mL 0.3404 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt)1638750-95-4ADU-S100 disodiumMIW815 disodiumML RR-S2 CDA disodiumSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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    目录号：
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