2. Academic Validation
  3. Ginkgetin Alleviates Inflammation and Senescence by Targeting STING

Ginkgetin Alleviates Inflammation and Senescence by Targeting STING

  • Adv Sci (Weinh). 2025 Jan;12(2):e2407222. doi: 10.1002/advs.202407222.
Yadan Liu 1 2,  Jialin Ye 3 4,  Zisheng Fan 5 6,  Xiaolong Wu 1 7,  Yinghui Zhang 1 4,  Ruirui Yang 1 4,  Bing Jiang 1 2,  Yajie Wang 1 8,  Min Wu 1,  Jingyi Zhou 1,  Jingyi Meng 1 2,  Zhiming Ge 1 8,  Guizhen Zhou 1 5,  Yuan Zhu 1 2,  Yichuan Xiao 3 4,  Mingyue Zheng 1 2 4 5 6 8,  Sulin Zhang 1 4
Affiliations

Affiliations

  • 1 Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • 2 School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • 3 CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
  • 4 University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 5 Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • 6 Lingang Laboratory, Shanghai, 200031, China.
  • 7 School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
  • 8 School of Pharmacology Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.
PMID: 39558862 DOI: 10.1002/advs.202407222
Abstract

Ginkgo biloba extract is reported to have therapeutic effects on aging-related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient of Ginkgo biloba extract, can alleviate cellular senescence and improve pathologies in multiple tissues of aging mice. To reveal the molecular mechanism of Ginkgetin's Anti-aging effect, a graph convolutional network-based drug "on-target" pathway prediction algorithm for prediction is employed. The results indicate that the cGAS-STING pathway may be a potential target for Ginkgetin. Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy-terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. Furthermore, in vivo pharmacodynamic data showed that Ginkgetin effectively alleviates systemic inflammation in Trex1-/- mice and inhibits the abnormally activated STING signaling in aging mouse model. In summary, this study, utilizing an artificial intelligence algorithm combined with pharmacological methods, confirms STING serves as a critical target for Ginkgetin in alleviating inflammation and senescence. Importantly, this study elucidates the specific component and molecular mechanism underlying the Anti-aging effect of Ginkgo biloba extract, providing a robust theoretical basis for its therapeutic use.

Keywords

Ginkgetin; STING inhibitor; cGAS‐STING signaling; senescence; target identification.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z