2. Academic Validation
  3. Host stimulator of interferon genes is essential for the efficacy of anti-programmed cell death protein 1 inhibitors in non-small cell lung cancer

Host stimulator of interferon genes is essential for the efficacy of anti-programmed cell death protein 1 inhibitors in non-small cell lung cancer

  • Immunology. 2022 Jul 20. doi: 10.1111/imm.13549.
Li Zhou 1,  Qiuli Xu 2,  Litang Huang 2,  Ping Zhan 1,  Jiajia Jin 3,  Mingxiang Ye 1,  Hongbing Liu 1,  Fang Zhang 1,  Zimu Wang 1,  Jiaxin Liu 1,  Cen Chen 1,  Hedong Han 1,  Qun Zhang 4,  Suhua Zhu 1,  Jianan Ren 5,  Tangfeng Lv 1,  Yong Song 1
Affiliations

Affiliations

  • 1 Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
  • 2 Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Southeast University, Sch Med, Nanjing, Jiangsu, China.
  • 3 Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
  • 4 Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • 5 Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
PMID: 35859099 DOI: 10.1111/imm.13549
Abstract

The stimulator of interferon genes (STING) pathway is important for Anticancer immune responses. However, the relative contributions of host and tumour STING in anti-programmed cell death protein 1 (anti-PD-1) inhibitor responses in non-small cell lung Cancer (NSCLC) are unknown. STING expression in tumour and blood was associated with anti-PD-1 therapy in NSCLC patients; Moreover, loss of PD-1 inhibitor therapeutic potency was demonstrated in STING KO (knock out) splenocytes and STING KO mice. STING knock-down in tumour cells had no effect. STING on CD8+ T cells and host cells, not tumour cells, correlated with clinical effect of anti-PD-1 therapy in NSCLC patients. Finally, adoptive transfer of CD8+ T cells restored PD-1 inhibitor Anticancer effects. STING in host cells but not in tumour cells mediates anti-PD-1 inhibitor responses in Cancer Immunotherapy and could be used to select advantageous NSCLC patients from immunotherapy.

Keywords

TMEM173; immunotherapy; lung cancer; nontumor expression; predictive biomarker.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z