PSMA1 - proteasome 20S subunit alpha 1 Gene

中文名称：蛋白酶体 20S 亚基 alpha 1

种属: Homo sapiens

同用名: NU; HC2; PROS30; HEL-S-275

关于 PSMA1

功能概要

蛋白酶体是一种多催化蛋白酶复合物，具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码肽酶 T1A 家族的一个成员，即 20S 核心 alpha 亚基。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 1 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]