2. Gene
  3. KRT13 - keratin 13 Gene

KRT13 - keratin 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 13

种属: Homo sapiens

同用名: K13; CK13; WSN2

基因 ID: 3860 | 基因类型: protein coding

关于 KRT13

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,500,981-41,505,612 (from NCBI)

This gene has 9 transcripts (splice variants), 30 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 15373.8).

功能概要

该基因编码的蛋白质是角蛋白基因家族的一员。角蛋白是负责上皮细胞结构完整性的中间丝蛋白，可细分为细胞角蛋白和毛发角蛋白。大多数 I 型细胞角蛋白由排列成对异型角蛋白链的酸性蛋白组成。这种 I 型细胞角蛋白与角蛋白 4 配对，并在非角化复层上皮的基底层上表达。该基因和角蛋白 4 的突变与常染色体显性遗传疾病白色海绵痣有关。 I 型细胞角蛋白聚集在染色体 17q21.2 的区域。该基因的可变剪接导致多个转录变体；然而，并未描述所有变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

KRT13 基因产物(2)

mRNA Protein Name
NM_002274.4 NP_002265.3 keratin, type I cytoskeletal 13 isoform b
NM_153490.3 NP_705694.3 keratin, type I cytoskeletal 13 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25910212 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoskeleton organization IDA
IDA: 通过直接分析推断
21371075 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular exosome IDA
IDA: 通过直接分析推断
21557262 GOA
located in intermediate filament cytoskeleton IDA
IDA: 通过直接分析推断
21371075 GOA
located in keratin filament IDA
IDA: 通过直接分析推断
9714826 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT13 蛋白结构

Filament

Filament: Intermediate filament protein (103 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

keratin, type I cytoskeletal 13

CK-13

KRT13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KRT13 P13646 DES Homo sapiens P17661
Validated Y2H
32296183
种属内
KRT13 P13646 KRT72 Homo sapiens Q14CN4
Validated Y2H
32296183
种属内
KRT13 P13646 KRT2 Homo sapiens P35908
Y2H Array
31515488
种属内
KRT13 P13646 HOOK3 Homo sapiens Q86VS8
Validated Y2H
32296183
种属内
KRT13 P13646 KRT4 Homo sapiens P19013
Y2H Prey Pooling
32296183
种属内
KRT13 P13646 KRT4 Homo sapiens P19013
Validated Y2H
32296183
种属内
KRT13 P13646 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
种属内
KRT13 P13646 TXLNB Homo sapiens Q8N3L3
Validated Y2H
32296183
种属内
KRT13 P13646 KRT6A Homo sapiens P02538
MAPPIT
32296183
种属内
KRT13 P13646 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
KRT13 P13646 GFAP Homo sapiens P14136
Validated Y2H
32296183
种属内
KRT13 P13646 GLYCTK Homo sapiens Q8IVS8
Validated Y2H
32296183
种属内
KRT13 P13646 KRT74 Homo sapiens Q7RTS7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

KRT13 抗体

目录号 产品名 应用 反应物种
HY-P82950 Cytokeratin 13 Antibody (YA2695) WB, IHC-P, ICC/IF Human, Mouse

关联疾病

疾病名称 别名
White Sponge Nevus 2

WSN2
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Inverted Papilloma

Inverted Papilloma, Squamous Cell

Papilloma Inverted

Papilloma, Inverted

Inverted Squamous Cell Papilloma
Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma
Frontal Sinus Inverted Papilloma

Inverted Papilloma Of The Frontal Sinus
Papilloma

Papillomatosis
Leukoplakia

Leukoplakia Of Gingiva

Leukoplakia Of Oral Epithelium

Leucoplakia Of Oral Mucosa

Leukokeratosis Of Oral Mucosa
Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus
Lichen Planus

Lichen Ruber Planus

Lichen, Ruber Planus

Ruber Planus

Lp - [Lichen Planus]

Lichen Planus Of Wilson

Wilson Lichen Ruber
Human Papillomavirus Infectious Disease

Hpv

Papillomavirus Infections

Human Papilloma Virus Infection
Thymic Carcinoma

Malignant Thymoma

Thymoma, Malignant
Transitional Papilloma

Transitional Cell Papilloma

Transitional Cell Papilloma, Benign
Ovarian Brenner Tumor

Benign Ovarian Brenner Tumor

Brenner Tumor

Benign Ovarian Brenner Tumour

Ovarian Brenner Tumour

Brenner Tumor Of Ovary

Benign Brenner Tumor
Mucoepidermoid Carcinoma

Mec

Salivary Gland Mucoepidermoid Carcinoma

C3772

Carcinoma Mucoepidermoid

Carcinoma, Mucoepidermoid
Vulva Cancer

Vulvar Carcinoma

Malignant Neoplasm Of Vulva

Vulva Carcinoma

Carcinoma Of Vulva

Vulvar Cancer

Vulval Cancer

Vulvar Neoplasms

Ca Vulva

Malignant Tumor Of Vulva

Malignant Vulvar Tumor

Neoplasm Of Vulva

Vulval Neoplasm

Vulvar Neoplasm

Vulvar Tumor

Cancer Of Vulva

Malignant Tumour Of Vulva
Keratitis, Hereditary

Keratitis

Autosomal Dominant Keratitis

Hereditary Keratitis

Dominantly Inherited Keratitis

Keratitis Hereditary

KERH
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Pigmented Basal Cell Carcinoma

Skin Pigmented Basal Cell Carcinoma
Skin Benign Neoplasm

Neoplasm Of Skin By Site

Tumor Of The Skin

Skin Tumor

Benign Neoplasm Of Skin

Skin Neoplasms
Lip And Oral Cavity Cancer

Oral Cancer

Lip And Oral Cavity Carcinoma

Malignant Neoplasm Of Mouth
Cicatricial Pemphigoid

Mucous Membrane Pemphigoid

Ocular Pemphigoid

Benign Mucous Membrane Pemphigoid

Benign Mucous Membrane Pemphigoid With Ocular Involvement

Benign Mucosal Pemphigoid

Pemphigoid, Benign Mucous Membrane

Cicatricial Pemphigoid With Ocular Involvement

Ocular Pemphigus

Cicatricial Pemphigoid Disease

Mucosal Pemphigoid

Mucosynechial Pemphigoid

Pemphigoid Cicatricial

Cicatricial Pemphigoid Involving The Eye

Ocular Cicatricial Pemphigoid
Cortical Thymoma

Polygonal Cell Thymoma

Thymoma, Cortical

Thymoma, Type B2
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome

Rudiger Syndrome 1

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1

EEC1

Eec Syndrome 1

Eec Syndrome-1

Walker-Clodius Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome

Eec

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly-Cleft Lip/Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome

Ectrodactyly-Cleft Lip-Palate Syndrome

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex

Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex

Beec

Eec

Exstrophy Of The Bladder

Bladder Exstrophy

Bladder Exstrophy And Epispadias Complex
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial
Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder
Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome

Toxic Epidermal Necrolysis

Drug-Induced Stevens Johnson Syndrome

Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Susceptibility To Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Lyell'S Syndrome

Lyell Syndrome

Severe Cutaneous Adverse Reaction, Susceptibility To

Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To

Hypersensitivity Syndrome, Carbamazepine-Induced

Stevens-Johnson Syndrome, Susceptibility To

Toxic Epidermal Necrolysis, Susceptibility To

Sjs/Ten

Susceptibility To Severe Cutaneous Adverse Reaction Ity To

Mycoplasma-Induced Stevens Johnson Syndrome

Dermatostomatitis, Stevens Johnson Type

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum

Sjs-Ten

Toxic Epidermolysis

SJS

Dermatostomatitis Stevens Johnson Type

Ten

Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]

Ten - [Toxic Epidermal Necrolysis]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07436 KRT13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KRT13 MGD MGI:101925
Canis familiaris KRT13 VGNC VGNC:55619
Rattus norvegicus KRT13 RGD RGD:1302937
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