2. Gene
  3. KRT2 - keratin 2 Gene

KRT2 - keratin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 2

种属: Homo sapiens

同用名: K2e; KRTE; CK-2e; KRT2A; KRT2E

基因 ID: 3849 | 基因类型: protein coding

关于 KRT2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,644,558-52,652,211 (from NCBI)

This gene has 2 transcripts (splice variants), 78 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward skin (RPKM 1015.4).

功能概要

该基因编码的蛋白质是角蛋白基因家族的一员。 II 型细胞角蛋白由碱性或中性蛋白组成，这些蛋白排列成对异型角蛋白链，在单层和复层上皮组织分化过程中共同表达。这种 II 型细胞角蛋白主要在表皮角质形成细胞的上棘层中表达，并且该基因的突变与大疱性先天性鱼鳞病样红皮病有关。 II 型细胞角蛋白聚集在染色体 12q12-q13 的区域中。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT2 基因产物(1)

mRNA Protein Name
NM_000423.3 NP_000414.2 keratin, type II cytoskeletal 2 epidermal
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables structural constituent of skin epidermis IDA
IDA: 通过直接分析推断
7543090 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in keratinization IDA
IDA: 通过直接分析推断
12598329 GOA
involved in keratinocyte activation IDA
IDA: 通过直接分析推断
12598329 GOA
involved in keratinocyte migration IDA
IDA: 通过直接分析推断
15737202 GOA
involved in keratinocyte proliferation IDA
IDA: 通过直接分析推断
12598329 GOA
involved in peptide cross-linking IDA
IDA: 通过直接分析推断
7543090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cornified envelope IDA
IDA: 通过直接分析推断
7543090 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
32179842 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT2 蛋白结构

Filament

Filament: Intermediate filament protein (177 - 490)

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  • 639 a.a.
蛋白主名 其他名称

keratin, type II cytoskeletal 2 epidermal

cytokeratin-2e

KRT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
25910212
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Array
25910212
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT40 Homo sapiens Q6A162
SLC
25910212
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
25910212
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Validated Y2H
25910212
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT38 Homo sapiens O76015
SLC
25910212
Intra KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
31515488
Intra KRT2 P35908 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra KRT2 P35908 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra KRT2 P35908 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra KRT2 P35908 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra KRT2 P35908 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra KRT2 P35908 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Array
31515488
Intra KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT13 Homo sapiens P13646
Validated Y2H
25910212
Intra KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Array
25910212
Intra KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra KRT2 P35908 KRT15 Homo sapiens P19012
SLC
25910212
Intra KRT2 P35908 KRT15 Homo sapiens P19012
Validated Y2H
25910212
Intra KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Array
25910212
Intra KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Validated Y2H
25910212
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
25910212
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Validated Y2H
25416956
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
25416956
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
25910212
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Bait-Prey Pool
25910212
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
25910212
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra KRT2 P35908 KRT31 Homo sapiens Q15323
SLC
25910212
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ichthyosis Bullosa Of Siemens

IBS

Ichthyosis, Bullous Type

Bullous Type Of Ichthyosis

Ichthyosis Bullous Type
Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset
Exfoliative Ichthyosis

Ichthyosis Exfoliativa

Autosomal Recessive Exfoliative Ichthyosis
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Epidermolytic Acanthoma
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma

Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

FNEPPK1

Ppkfne

Keratoderma, Focal Nonepidermolytic Palmoplantar

Palmoplantar Keratoderma, Nonepidermolytic, Focal

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Fneppk

Focal Nonepidermolytic Palmoplantar Keratoderma 1

Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome
Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Dowling-Degos Disease

Reticular Pigment Anomaly Of Flexures

Dark Dot Disease

Reticulate Acropigmentation Of Kitamura

Dowling-Degos Kitamura Disease

Kitamura Reticulate Acropigmentation

Ddd

Dowling-Degos-Kitamura Disease

Reticular Pigmented Anomaly Of Flexures
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07443 KRT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus KRT2 VGNC VGNC:30721
Mus musculus KRT2 MGD MGI:96699
Rattus norvegicus KRT2 RGD RGD:1303297
Canis familiaris KRT2 VGNC VGNC:42520
Macaca mulatta KRT2 VGNC VGNC:74212
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