1. Gene
  2. KRT16 - keratin 16 Gene

KRT16 - keratin 16 Gene

中文名称:角蛋白 16

种属: Homo sapiens

同用名: K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A

基因 ID: 3868 | 基因类型: protein coding

关于 KRT16

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,609,778-41,612,767 (from NCBI)

This gene has 4 transcripts (splice variants), 85 orthologues, 68 paralogues and is associated with 7 phenotypes. Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8).

功能概要

该基因编码的蛋白质是角蛋白基因家族的一员。角蛋白是负责上皮细胞结构完整性的中间丝蛋白,可细分为细胞角蛋白和毛发角蛋白。大多数 I 型细胞角蛋白由成对异型角蛋白链排列并聚集在染色体 17q12-q21 区域的酸性蛋白组成。这种角蛋白与角蛋白 14 在许多上皮组织中共表达,包括食道、舌头和毛囊。该基因的突变与 1 型先天性厚甲、非表皮松解性掌跖角化病和单侧掌跖疣状痣有关。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

KRT16 基因产物(1)

mRNA Protein Name
NM_005557.4 NP_005548.2 keratin, type I cytoskeletal 16
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15731013 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hair cycle IDA
IDA: 通过直接分析推断
21916889 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
20403371 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoskeleton IDA
IDA: 通过直接分析推断
20403371 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KRT16 蛋白结构

Filament

Filament: Intermediate filament protein (116 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

keratin, type I cytoskeletal 16

cytokeratin 16

KRT16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KRT16 P08779 CCHCR1 Homo sapiens Q8TD31-3 32296183
种属内
KRT16 P08779 GNG10 Homo sapiens P50151 32296183
种属内
KRT16 P08779 KRT83 Homo sapiens P78385 32296183
种属内
KRT16 P08779 SEMA4C Homo sapiens Q9C0C4 32296183
种属内
KRT16 P08779 POLL Homo sapiens Q9UGP5-2 32296183
种属内
KRT16 P08779 KRT85 Homo sapiens P78386 32296183
种属内
KRT16 P08779 KRT78 Homo sapiens Q8N1N4 32296183
种属内
KRT16 P08779 CCDC146 Homo sapiens Q8IYE0 32296183
种属内
KRT16 P08779 CYTH4 Homo sapiens Q9UIA0 32296183
种属内
KRT16 P08779 CARD9 Homo sapiens Q9H257-2 32296183
种属内
KRT16 P08779 PUS10 Homo sapiens Q3MIT2 32296183
种属内
KRT16 P08779 KRT80 Homo sapiens Q6KB66-2 32296183
种属内
KRT16 P08779 KRT73 Homo sapiens Q86Y46-2 32296183
种属内
KRT16 P08779 CCDC17 Homo sapiens Q96LX7-5 32296183
种属内
KRT16 P08779 KRT72 Homo sapiens Q14CN4 32296183
种属内
KRT16 P08779 KRT2 Homo sapiens P35908 32296183
种属内
KRT16 P08779 PRKAA2 Homo sapiens P54646 32296183
种属内
KRT16 P08779 KIFC3 Homo sapiens Q9BVG8-5 32296183
种属内
KRT16 P08779 KRT4 Homo sapiens P19013 32296183
种属内
KRT16 P08779 KRT3 Homo sapiens P12035 32296183
种属内
KRT16 P08779 KRT79 Homo sapiens Q5XKE5 32296183
种属内
KRT16 P08779 PPP1R18 Homo sapiens Q6NYC8 32296183
种属内
KRT16 P08779 KRT6C Homo sapiens P48668 32296183
种属内
KRT16 P08779 KRT71 Homo sapiens Q3SY84 32296183
种属内
KRT16 P08779 KRT76 Homo sapiens Q01546 32296183
种属内
KRT16 P08779 TSG101 Homo sapiens Q99816 32296183
种属内
KRT16 P08779 SMARCD1 Homo sapiens Q96GM5 32296183
种属内
KRT16 P08779 SMARCD1 Homo sapiens Q96GM5 32296183
种属内
KRT16 P08779 CCNC Homo sapiens P24863 32296183
种属内
KRT16 P08779 SMARCE1 Homo sapiens Q969G3 32296183
种属内
KRT16 P08779 PKN1 Homo sapiens Q16512 32296183
种属内
KRT16 P08779 TXLNB Homo sapiens Q8N3L3 32296183
种属内
KRT16 P08779 EPM2AIP1 Homo sapiens Q7L775 32296183
种属内
KRT16 P08779 ARFIP2 Homo sapiens P53365 32296183
种属内
KRT16 P08779 KRT5 Homo sapiens P13647 32296183
种属内
KRT16 P08779 KRT81 Homo sapiens Q14533 32296183
种属内
KRT16 P08779 LNX1 Homo sapiens Q8TBB1 32296183
种属内
KRT16 P08779 USHBP1 Homo sapiens Q8N6Y0 32296183
种属内
KRT16 P08779 TCHP Homo sapiens Q9BT92 32296183
种属内
KRT16 P08779 SGF29 Homo sapiens Q96ES7 32296183
种属内
KRT16 P08779 SGF29 Homo sapiens Q96ES7 33961781
种属内
KRT16 P08779 CDK18 Homo sapiens Q07002 32296183
种属内
KRT16 P08779 C1orf216 Homo sapiens Q8TAB5 32296183
种属内
KRT16 P08779 PRPH Homo sapiens P41219 32296183
种属内
KRT16 P08779 LMO1 Homo sapiens P25800 32296183
种属内
KRT16 P08779 AIRIM Homo sapiens Q9NX04 32296183
种属内
KRT16 P08779 TTC23 Homo sapiens Q5W5X9-3 32296183
种属内
KRT16 P08779 KLC4 Homo sapiens Q9NSK0 32296183
种属内
KRT16 P08779 KRT74 Homo sapiens Q7RTS7 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

KRT16 抗体

目录号 产品名 应用 反应物种
HY-P81266 Cytokeratin 16 Antibody (YA948) WB, IHC-P Human, Mouse, Rat
HY-P81266A Cytokeratin 16 Antibody (YA949) WB, IHC-P Human

关联疾病

疾病名称 别名
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2

Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma

Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

FNEPPK1

Ppkfne

Keratoderma, Focal Nonepidermolytic Palmoplantar

Palmoplantar Keratoderma, Nonepidermolytic, Focal

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Fneppk

Focal Nonepidermolytic Palmoplantar Keratoderma 1

Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1

Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Bowen'S Disease

Bowens Disease

Palmoplantar Keratoderma, Nonepidermolytic

Nonepidermolytic Palmoplantar Keratoderma

NEPPK

Tylosis

Unna-Thost Syndrome

Keratoderma, Palmoplantar, Diffuse

Ppkne

Keratoderma, Nonepidermolytic Palmoplantar

Diffuse Nonepidermolytic Palmomplantar Keratoderma

Thost-Unna Syndrome

Non-Epidermolytic Palmoplantar Keratoderma

Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type

Diffuse Palmoplantar Keratoderma, Bothnian Type

Krt1-Related Diffuse Nonepidermolytic Keratoderma

Krt1-Related Diffuse Neppk

Keratoderma, Palmoplantar, Non-Epidermolytic

Nonepidermolytic Unna-Thost Disease

Non-Epidermolytic Unna-Thost Disease

Keratoderma, Palmoplantar, Nonepidermolytic

Hyperkeratosis

Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset

Pachyonychia Congenita 2

Pachyonychia Congenita, Type 2

PC2

Pachyonychia Congenita, Jackson-Lawler Type, Formerly

Pachyonychia Congenita Jackson-Lawler Type

Palmoplantar Keratosis

Palmoplantar Keratoderma

Keratosis Palmaris Et Plantaris

Palmo-Plantar Keratodermas

Keratoderma, Palmoplantar

Keratoderma Palmoplantar

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis Of Palms And Soles

Palmoplantar Hyperkeratosis

Hypertrophic Scars

Scars Hypertrophic

Hypertrophic Scarring

Psoriasis
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome

Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma

Focal Palmoplantar Keratoderma

Focal Ppk

Focal Keratosis Palmoplantaris

Focal Palmoplantar Hyperkeratosis

Keratosis

Actinic Keratosis

Hyperkeratosis

Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa

Lichen Planus

Lichen Ruber Planus

Lichen, Ruber Planus

Ruber Planus

Lp - [Lichen Planus]

Lichen Planus Of Wilson

Wilson Lichen Ruber

Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis

Epidermolysis Bullosa

Acantholysis Bullosa

Eb

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Glossitis

Inflammation Of Tongue

Tongue Inflammation

Glazed Tongue

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade

Corneal Dystrophy
Irritant Dermatitis

Irritant Contact Dermatitis

Primary Irritant Dermatitis

Dermatitis, Irritant

Contact Dermatitis, Irritant

Irritant Contact Eczema

Icd - [Irritant Contact Dermatitis]

Irritant Contact Dermatitis, Unspecified Cause

Non-Allergic Contact Dermatitis

Irritant Contact Eczema Due To Wet Work

Irritant Contact Dermatitis Due To Detergents

Irritant Contact Eczema Due To Solvents

Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

Irritant Contact Eczema Due To Cosmetics Or Emollients

Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

Irritant Contact Eczema Due To Foods

Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

Irritant Contact Eczema Due To Saliva

Irritant Contact Eczema Due To Incontinence

Incontinence-Associated Dermatitis

Epidermolysis Bullosa Simplex Localized Type

Epidermolysis Bullosa Simplex, Weber-Cockayne Type

Weber-Cockayne Syndrome

Ebs-Loc

Epidermolysis Bullosa Simplex Of Palms And Soles

Epidermolysis Bullosa Simplex Weber-Cockayne Type

Epidermolysis Bullosa Simplex, Localized

Epidermolysis Bullosa Of Hands And Feet

Weber-Cockayne Type Epidermolysis Bullosa Simplex

Localized Epidermolysis Bullosa Simplex

Localized Ebs

Autoimmune Disease Of Skin And Connective Tissue
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus KRT16 MGD MGI:96690
Rattus norvegicus KRT16 RGD RGD:1590901
Macaca mulatta KRT16 VGNC VGNC:74210