KLC4 - kinesin light chain 4 Gene

中文名称：驱动蛋白轻链 4

种属: Homo sapiens

同用名: KNSL8; bA387M24.3

基因 ID: 89953 | 基因类型: protein coding

关于 KLC4

This gene has 19 transcripts (splice variants), 381 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues.

功能概要

预测位于细胞质和微管中。预计是驱动蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be located in cytoplasm and microtubule. Predicted to be part of Kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]

KLC4 基因产物(6)

mRNA	Protein	Name
NM_001289034.2	NP_001275963.1	kinesin light chain 4 isoform a
NM_001289035.2	NP_001275964.1	kinesin light chain 4 isoform d
NM_138343.4	NP_612352.1	kinesin light chain 4 isoform c
NM_201521.3	NP_958929.1	kinesin light chain 4 isoform a
NM_201522.3	NP_958930.1	kinesin light chain 4 isoform a
NM_201523.3	NP_958931.1	kinesin light chain 4 isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLC4 蛋白结构

Rab5-bind

TPR_2

TPR_12

TPR_10

0
100
200
300
400
500
619 a.a.

蛋白主名

其他名称

kinesin light chain 4

kinesin-like protein 8

KLC4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SLC16A9	Homo sapiens	Q7RTY1	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KLC4	Q9NSK0	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Array	32296183
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Ehlers-Danlos Syndrome, Vascular Type

Eds Iv	Eds4
Vascular Ehlers-Danlos Syndrome	Veds
Sack-Barabas Syndrome	EDSVASC
Ehlers-Danlos Syndrome, Type Iv, Autosomal Dominant	Vascular Type Ehlers-Danlos Syndrome
Arterial-Ecchymotic Eds	Ehlers-Danlos Syndrome Type 4
Vascular Eds	Ehlers-Danlos Syndrome, Type 4
Ehlers-Danlos Syndrome, Type Iv	Ehlers-Danlos Syndrome, Arterial Type
Ehlers-Danlos Syndrome, Ecchymotic Type	Ehlers-Danlos Syndrome, Sack-Barabas Type
Autosomal Dominant Type Iv Ehlers-Danlos Syndrome	Eds Type Iv
Eds Type 4	Ehlers Danlos Syndrome, Sack-Barabas Type
Ehlers Danlos Syndrome, Arterial Type	Ehlers Danlos Syndrome, Ecchymotic Type
Ehlers-Danlos Syndrome Type Iv	Ehlers-Danlos Syndrome 4
Ehlers-Danlos Syndrome Arterial Type	Ehlers-Danlos Syndrome Ecchymotic Type
Ehlers-Danlos Syndrome, Type 4 Variant	Ehlers-Danlos, Vascular Type Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07329	KLC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	KLC4	VGNC	VGNC:73880
Felis catus	KLC4	VGNC	VGNC:63129
Canis familiaris	KLC4	VGNC	VGNC:42429
Rattus norvegicus	KLC4	RGD	RGD:1306555
Mus musculus	KLC4	MGD	MGI:1922014
Bos taurus	KLC4	VGNC	VGNC:30625

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLC4 - kinesin light chain 4 Gene

关于 KLC4

功能概要

KLC4 基因产物(6)

KLC4 蛋白结构

KLC4 蛋白互作信息

关联疾病

直系同源

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KLC4 - kinesin light chain 4 Gene

关于 KLC4

功能概要

KLC4 基因产物(6)

KLC4 蛋白结构

KLC4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z