KATNAL1 - katanin catalytic subunit A1 like 1 Gene

中文名称：katanin 催化亚基 A1 样 1

种属: Homo sapiens

基因 ID: 84056 | 基因类型: protein coding

关于 KATNAL1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,202,630-30,307,551 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 9 paralogues. Broad expression in testis (RPKM 4.9), brain (RPKM 4.4) and 24 other tissues.

功能概要

实现相同的蛋白质结合活性和微管切断 ATP 酶活性。参与微管切断。位于细胞质中；微管;和主轴杆。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and microtubule-severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

KATNAL1 基因产物(2)

mRNA	Protein	Name
NM_001014380.3	NP_001014402.1	katanin p60 ATPase-containing subunit A-like 1
NM_032116.5	NP_115492.1	katanin p60 ATPase-containing subunit A-like 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables microtubule severing ATPase activity	IDA IDA: 通过直接分析推断	26929214	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in microtubule severing	IDA IDA: 通过直接分析推断	26929214	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	26929214	GOA
part of katanin complex	IPI IPI: 通过物理相互作用推断	26929214	GOA
located in microtubule	IDA IDA: 通过直接分析推断	26929214	GOA
located in spindle	IDA IDA: 通过直接分析推断	26929214	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	26929214	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KATNAL1 蛋白结构

AAA

Vps4_C

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

katanin p60 ATPase-containing subunit A-like 1

katanin catalytic subunit A like 1

KATNAL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	KATNB1	Homo sapiens	Q9BVA0	TAP	26929214
Intra	KATNAL1	Q9BW62	KATNB1	Homo sapiens	Q9BVA0	Anti Tag CoIP	26929214
Intra	KATNAL1	Q9BW62	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PITPNC1	Homo sapiens	Q9UKF7-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PGAM2	Homo sapiens	P15259	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PGAM2	Homo sapiens	P15259	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Y2H Array	25416956
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	TAP	26929214
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Anti Tag CoIP	26929214
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	KATNAL1	Q9BW62	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KLC4	Homo sapiens	Q9NSK0	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KLC4	Homo sapiens	Q9NSK0	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Joubert Syndrome 26

JBTS26

Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07085	KATNAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KATNAL1	VGNC	VGNC:42217
Macaca mulatta	KATNAL1	VGNC	VGNC:73917
Rattus norvegicus	KATNAL1	RGD	RGD:1359252
Bos taurus	KATNAL1	VGNC	VGNC:30406
Mus musculus	KATNAL1	MGD	MGI:2387638
Felis catus	KATNAL1	VGNC	VGNC:63028

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