KATNB1 - katanin regulatory subunit B1 Gene

中文名称：katanin 调节亚基 B1

种属: Homo sapiens

同用名: KAT; LIS6

基因 ID: 10300 | 基因类型: protein coding

关于 KATNB1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,735,770-57,757,244 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 14.6), brain (RPKM 7.5) and 24 other tissues.

功能概要

微管是 α 和 β 微管蛋白亚基的聚合物，形成分裂细胞的有丝分裂纺锤体，并有助于在间期组织膜状细胞器。 Katanin 是一种异二聚体，由一个 60 kDa ATP 酶 (p60 亚基 A 1) 和一个 80 kDa 辅助蛋白 (p80 亚基 B 1) 组成。 p60 亚基用于切断和分解微管，而 p80 亚基将酶靶向中心体。 Katanin 是 ATA 酶 AAA 家族的成员。[RefSeq 提供，2008 年 7 月]

Microtubules, Polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the Enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

KATNB1 基因产物(1)

mRNA	Protein	Name
NM_005886.3	NP_005877.2	katanin p80 WD40 repeat-containing subunit B1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase regulator activity	IDA IDA: 通过直接分析推断	10751153	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24486153	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	10751153	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of microtubule depolymerization	IMP IMP: 通过突变表型推断	10751153	GOA
involved in positive regulation of microtubule depolymerization	IMP IMP: 通过突变表型推断	10751153	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10751153	GOA
part of katanin complex	IDA IDA: 通过直接分析推断	9568719	GOA
part of katanin complex	IPI IPI: 通过物理相互作用推断	26929214	GOA
located in microtubule	IDA IDA: 通过直接分析推断	26929214	GOA
located in spindle	IDA IDA: 通过直接分析推断	26929214	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	10751153	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KATNB1 蛋白结构

WD40

Katanin_con80

0
200
400
600
655 a.a.

蛋白主名

其他名称

katanin p80 WD40 repeat-containing subunit B1

katanin (80 kDa)

KATNB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KATNB1	Q9BVA0	KATNA1	Homo sapiens	O75449	Anti Tag CoIP	26929214
Intra	KATNB1	Q9BVA0	KATNA1	Homo sapiens	O75449	TAP	26929214
Intra	KATNB1	Q9BVA0	BTK	Homo sapiens	Q06187	Anti Tag CoIP	33961781
Intra	KATNB1	Q9BVA0	BTK	Homo sapiens	Q06187	Anti Tag CoIP	28514442
Intra	KATNB1	Q9BVA0	KATNAL1	Homo sapiens	Q9BW62	Anti Tag CoIP	26929214
Intra	KATNB1	Q9BVA0	KATNAL1	Homo sapiens	Q9BW62	TAP	26929214

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lissencephaly 6 With Microcephaly

Lissencephaly 6, With Microcephaly	LIS6
Lissencephaly, Type 6, With Microcephaly

Lissencephaly 2

Norman-Roberts Syndrome	Lissencephaly Syndrome, Norman-Roberts Type
LIS2	Lissencephaly With Cerebellar Hypoplasia
Lch	Lissencephaly Syndrome Norman-Roberts Type
Norman Roberts Lissencephaly Syndrome	Lissencephaly 3
Lis3	Microlissencephaly Type A
Norman-Roberts Lissencephaly Syndrome	Lissencephaly, Type 2
Cobblestone Lissencephaly

Lissencephaly 6

Lis6

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Microlissencephaly

Acromelic Frontonasal Dysostosis

AFND	Acromelic Frontonasal Dysplasia
Frontonasal Dysplasia Acromelic	Toriello Syndrome
Dysostosis, Acromelic Frontonasal	Sweet Syndrome

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Joubert Syndrome 26

JBTS26

Polymicrogyria, Bilateral Temporooccipital

Bilateral Parasagittal Parieto-Occipital Polymicrogyria	BTOP
Bilateral Temporooccipital Polymicrogyria	Polymicrogyria

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Microcephaly 5, Primary, Autosomal Recessive

MCPH5	Primary Autosomal Recessive Microcephaly 5
Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern	Microcephaly, Primary Autosomal Recessive, 5

Mannosidosis, Beta A, Lysosomal

Beta-Mannosidosis	Lysosomal Beta-Mannosidase Deficiency
Beta-Mannosidase Deficiency	Beta-D-Mannosidosis
Mannosidosis, Beta	MANSB
Lysosomal Beta A Mannosidosis

Band Heterotopia

Subcortical Band Heterotopia	Double Cortex Syndrome
Subcortical Laminar Heterotopia	Double Cortex
Band Heterotopia Of Brain	BH
Heco	Heterotopic Cortex
Familial Band Heterotopia	Dc
Dc Syndrome	Heterotopia, Subcortical Band
Sbh	Sclh
Bhy

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07087	KATNB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KATNB1	RGD	RGD:1311256
Felis catus	KATNB1	VGNC	VGNC:67888
Mus musculus	KATNB1	MGD	MGI:1921437
Macaca mulatta	KATNB1	VGNC	VGNC:73962
Bos taurus	KATNB1	VGNC	VGNC:30408
Canis familiaris	KATNB1	VGNC	VGNC:54758

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KATNB1 - katanin regulatory subunit B1 Gene

关于 KATNB1

功能概要

KATNB1 基因产物(1)

KATNB1 蛋白结构

KATNB1 蛋白互作信息

关联疾病

直系同源

热门区域

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KATNB1 - katanin regulatory subunit B1 Gene

关于 KATNB1

功能概要

KATNB1 基因产物(1)

KATNB1 蛋白结构

KATNB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z