2. Gene
  3. ASCC2 - activating signal cointegrator 1 complex subunit 2 Gene

ASCC2 - activating signal cointegrator 1 complex subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活信号协整子 1 复杂亚基 2

种属: Homo sapiens

同用名: p100; ASC1p100

基因 ID: 84164 | 基因类型: protein coding

关于 ASCC2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,788,611-29,838,274 (from NCBI)

This gene has 23 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in bone marrow (RPKM 13.0), testis (RPKM 12.7) and 25 other tissues.

功能概要

预测启用泛素结合活性。参与转录调控，以 DNA 为模板；拯救停滞的核糖体；和核糖体相关的泛素依赖性蛋白质分解代谢过程。位于核内。激活信号协积分子 1 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ubiquitin binding activity. Involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of activating signal cointegrator 1 complex. [provided by Alliance of Genome Resources, Apr 2022]

ASCC2 基因产物(33)

mRNA Protein Name
NM_001242906.2 NP_001229835.1 activating signal cointegrator 1 complex subunit 2 isoform 2
NM_001369920.1 NP_001356849.1 activating signal cointegrator 1 complex subunit 2 isoform 3
NM_001369921.1 NP_001356850.1 activating signal cointegrator 1 complex subunit 2 isoform 1
NM_001369922.1 NP_001356851.1 activating signal cointegrator 1 complex subunit 2 isoform 1
NM_001369923.1 NP_001356852.1 activating signal cointegrator 1 complex subunit 2 isoform 1
NM_001369924.1 NP_001356853.1 activating signal cointegrator 1 complex subunit 2 isoform 4
NM_001369925.1 NP_001356854.1 activating signal cointegrator 1 complex subunit 2 isoform 5
NM_001369926.1 NP_001356855.1 activating signal cointegrator 1 complex subunit 2 isoform 6
NM_001369927.1 NP_001356856.1 activating signal cointegrator 1 complex subunit 2 isoform 6
NM_001369928.1 NP_001356857.1 activating signal cointegrator 1 complex subunit 2 isoform 6
NM_001369929.1 NP_001356858.1 activating signal cointegrator 1 complex subunit 2 isoform 7
NM_001369930.1 NP_001356859.1 activating signal cointegrator 1 complex subunit 2 isoform 8
NM_001369931.1 NP_001356860.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369932.1 NP_001356861.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369933.1 NP_001356862.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369934.1 NP_001356863.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369935.1 NP_001356864.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369936.1 NP_001356865.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369937.1 NP_001356866.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369938.1 NP_001356867.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369939.1 NP_001356868.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369940.1 NP_001356869.1 activating signal cointegrator 1 complex subunit 2 isoform 9
NM_001369941.1 NP_001356870.1 activating signal cointegrator 1 complex subunit 2 isoform 10
NM_001369942.1 NP_001356871.1 activating signal cointegrator 1 complex subunit 2 isoform 11
NM_001369943.1 NP_001356872.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369944.1 NP_001356873.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369945.1 NP_001356874.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369946.1 NP_001356875.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369947.1 NP_001356876.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369948.1 NP_001356877.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369949.1 NP_001356878.1 activating signal cointegrator 1 complex subunit 2 isoform 12
NM_001369950.1 NP_001356879.1 activating signal cointegrator 1 complex subunit 2 isoform 13
NM_032204.5 NP_115580.2 activating signal cointegrator 1 complex subunit 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
36302773 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12077347 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
32579943 GOA
involved in rescue of stalled ribosome IMP
IMP: 通过突变表型推断
32099016 GOA
involved in ribosome disassembly IDA
IDA: 通过直接分析推断
32579943 GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
32099016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA repair complex IPI
IPI: 通过物理相互作用推断
29997253 GOA
part of activating signal cointegrator 1 complex IDA
IDA: 通过直接分析推断
12077347 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
36302773 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12077347 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASCC2 蛋白结构

CUE

CUE: CUE domain (469 - 508)

  • 0
  • 200
  • 400
  • 600
  • 757 a.a.
蛋白主名 其他名称

activating signal cointegrator 1 complex subunit 2

ASC-1 complex subunit P100

ASCC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ASCC2 Q9H1I8 ASCC3 Homo sapiens Q8N3C0
IF
29997253
Intra ASCC2 Q9H1I8 ASCC3 Homo sapiens Q8N3C0
Anti Tag CoIP
33961781
Intra ASCC2 Q9H1I8 ASCC3 Homo sapiens Q8N3C0
Anti Tag CoIP
28514442
Intra ASCC2 Q9H1I8 ASCC3 Homo sapiens Q8N3C0
Pull Down
29997253
Intra ASCC2 Q9H1I8 ASCC3 Homo sapiens Q8N3C0
Anti Tag CoIP
29997253
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01076 ASCC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ASCC2 VGNC VGNC:59967
Macaca mulatta ASCC2 VGNC VGNC:69895
Canis familiaris ASCC2 VGNC VGNC:38171
Bos taurus ASCC2 VGNC VGNC:26204
Rattus norvegicus ASCC2 RGD RGD:1561422
Mus musculus ASCC2 MGD MGI:1922702
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