2. Gene
  3. ASCC3 - activating signal cointegrator 1 complex subunit 3 Gene

ASCC3 - activating signal cointegrator 1 complex subunit 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活信号协整子 1 复杂亚基 3

种属: Homo sapiens

同用名: RNAH; HELIC1; ASC1p200

基因 ID: 10973 | 基因类型: protein coding

关于 ASCC3

Cytogenetic location: 6q16.3 Genomic coordinates (GRCh38): 6:100,508,194-100,881,329 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in urinary bladder (RPKM 5.0), colon (RPKM 4.9) and 25 other tissues.

功能概要

该基因编码的蛋白质属于解旋酶家族，参与核酸双链体的 ATP 依赖性解旋。编码的蛋白质是参与 DNA 修复和抗烷基化损伤的激活信号共整合子 1 复合体的最大亚基。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ASCC3 基因产物(3)

mRNA Protein Name
NM_001284271.2 NP_001271200.1 activating signal cointegrator 1 complex subunit 3 isoform c
NM_006828.4 NP_006819.2 activating signal cointegrator 1 complex subunit 3 isoform a
NM_022091.5 NP_071374.1 activating signal cointegrator 1 complex subunit 3 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' DNA helicase activity IDA
IDA: 通过直接分析推断
22055184 GOA
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
32579943 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22055184 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA alkylation repair IDA
IDA: 通过直接分析推断
22055184 GOA
involved in DNA duplex unwinding IDA
IDA: 通过直接分析推断
22055184 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
32579943 GOA
involved in rescue of stalled ribosome IMP
IMP: 通过突变表型推断
32099016 GOA
involved in ribosome disassembly IDA
IDA: 通过直接分析推断
32579943 GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
32099016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA repair complex IPI
IPI: 通过物理相互作用推断
29997253 GOA
part of activating signal cointegrator 1 complex IDA
IDA: 通过直接分析推断
12077347 GOA
located in cytosol IDA
IDA: 通过直接分析推断
28757607 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
36302773 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12077347 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASCC3 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (479 - 653)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (779 - 856)

Sec63

Sec63: Sec63 Brl domain (978 - 1287)

DEAD

DEAD: DEAD/DEAH box helicase (1329 - 1494)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1616 - 1693)

Sec63

Sec63: Sec63 Brl domain (1812 - 2176)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2202 a.a.
蛋白主名 其他名称

activating signal cointegrator 1 complex subunit 3

ASC-1 complex subunit P200

ASCC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ASCC3 Q8N3C0 HCCS Homo sapiens P53701
Anti Tag CoIP
33961781
种属内
ASCC3 Q8N3C0 HCCS Homo sapiens P53701
Anti Tag CoIP
28514442
种属内
ASCC3 Q8N3C0 ASCC2 Homo sapiens Q9H1I8
Anti Bait CoIP
29997253
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01077 ASCC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ASCC3 VGNC VGNC:69863
Felis catus ASCC3 VGNC VGNC:59968
Mus musculus ASCC3 MGD MGI:1925237
Canis familiaris ASCC3 VGNC VGNC:38172
Rattus norvegicus ASCC3 RGD RGD:1307995
Bos taurus ASCC3 VGNC VGNC:26205
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