1. Gene
  2. SEMA4C - semaphorin 4C Gene

SEMA4C - semaphorin 4C Gene

中文名称:信号素 4C

种属: Homo sapiens

同用名: SEMAF; SEMAI; SEMACL1; M-SEMA-F

基因 ID: 54910 | 基因类型: protein coding

关于 SEMA4C

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,859,718-96,870,830 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues.

功能概要

预测具有化学排斥活性和脑信号素受体结合活性。参与肌肉细胞分化和应激激活的 MAPK 级联的正调节。位于细胞外空间。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4C 基因产物(1)

mRNA Protein Name
NM_017789.5 NP_060259.4 semaphorin-4C precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in muscle cell differentiation IDA
IDA: 通过直接分析推断
17498836 GOA
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
17498836 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SEMA4C 蛋白结构

Sema

Sema: Sema domain (55 - 480)

PSI

PSI: Plexin repeat (499 - 530)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
蛋白主名 其他名称

semaphorin-4C

M-Sema F

SEMA4C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEMA4C Q9C0C4 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra SEMA4C Q9C0C4 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra SEMA4C Q9C0C4 CACNA1C Homo sapiens Q13936
Anti Bait CoIP
37207277
Intra SEMA4C Q9C0C4 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra SEMA4C Q9C0C4 HCN1 Homo sapiens O60741
Anti Bait CoIP
37207277
Intra SEMA4C Q9C0C4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra SEMA4C Q9C0C4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra SEMA4C Q9C0C4 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra SEMA4C Q9C0C4 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra SEMA4C Q9C0C4 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra SEMA4C Q9C0C4 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra SEMA4C Q9C0C4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SEMA4C Q9C0C4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra SEMA4C Q9C0C4 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SEMA4C Q9C0C4 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SEMA4C Q9C0C4 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SEMA4C Q9C0C4 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra SEMA4C Q9C0C4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra SEMA4C Q9C0C4 RCHY1 Homo sapiens Q96PM5
Validated Y2H
25416956
Intra SEMA4C Q9C0C4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra SEMA4C Q9C0C4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra SEMA4C Q9C0C4 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra SEMA4C Q9C0C4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra SEMA4C Q9C0C4 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra SEMA4C Q9C0C4 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra SEMA4C Q9C0C4 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SEMA4C VGNC VGNC:103862
Canis familiaris SEMA4C VGNC VGNC:45996
Rattus norvegicus SEMA4C RGD RGD:1562837
Mus musculus SEMA4C MGD MGI:109252
Bos taurus SEMA4C VGNC VGNC:34435
Felis catus SEMA4C VGNC VGNC:64994
Others SEMA4C NCBI