HCN1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

中文名称：超极化激活环核苷酸门控钾通道 1

种属: Homo sapiens

同用名: BCNG1; DEE24; HAC-2; BCNG-1; EIEE24; GEFSP10

基因 ID: 348980 | 基因类型: protein coding

关于 HCN1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:45,254,948-45,696,380 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues, 17 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 4.9), heart (RPKM 0.8) and 1 other tissue.

功能概要

由该基因编码的膜蛋白是一种超极化激活的阳离子通道，有助于心脏和神经元中的天然起搏器电流。编码的蛋白质可以与其他成孔亚基同二聚化或异二聚化形成钾通道。这个通道可以作为酸味的受体。[RefSeq 提供，2011 年 10 月]

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with Other pore-forming subunits to form a Potassium Channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

HCN1 基因产物(1)

mRNA	Protein	Name
NM_021072.4	NP_066550.2	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cAMP binding	IDA IDA: 通过直接分析推断	28086084	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	26966193	GOA
enables voltage-gated monoatomic cation channel activity	IDA IDA: 通过直接分析推断	28086084	GOA
enables voltage-gated potassium channel activity	IMP IMP: 通过突变表型推断	22748890	GOA
enables voltage-gated sodium channel activity	IMP IMP: 通过突变表型推断	22748890	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to cAMP	IDA IDA: 通过直接分析推断	22748890	GOA
involved in cellular response to cAMP	IMP IMP: 通过突变表型推断	28086084	GOA
involved in potassium ion transmembrane transport	IMP IMP: 通过突变表型推断	22748890	GOA
involved in protein homotetramerization	IDA IDA: 通过直接分析推断	28086084	GOA
involved in regulation of membrane potential	IMP IMP: 通过突变表型推断	22748890	GOA
involved in sodium ion transmembrane transport	IMP IMP: 通过突变表型推断	22748890	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of HCN channel complex	IDA IDA: 通过直接分析推断	28086084	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	22748890	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCN1 蛋白结构

Ion_trans_N

Ion_trans

cNMP_binding

0
200
400
600
800
890 a.a.

蛋白主名

其他名称

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

brain cyclic nucleotide-gated channel 1

HCN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HCN1	O60741	SEMA4C	Homo sapiens	Q9C0C4	Anti Bait CoIP	37207277
种属内	HCN1	O60741	PYGB	Homo sapiens	P11216	Anti Bait CoIP	37207277
种属内	HCN1	O60741	AKAP11	Homo sapiens	Q9UKA4	Anti Bait CoIP	37207277
种属内	HCN1	O60741	HCN4	Homo sapiens	Q9Y3Q4	Anti Bait CoIP	37207277
种属内	HCN1	O60741	HCN4	Homo sapiens	Q9Y3Q4	Anti Tag CoIP	33961781
种属内	HCN1	O60741	PCDHA2	Homo sapiens	Q9Y5H9	Anti Bait CoIP	37207277
种属内	HCN1	O60741	SYNGAP1	Homo sapiens	Q96PV0	Anti Bait CoIP	37207277
种属内	HCN1	O60741	HNRNPA2B1	Homo sapiens	P22626	Anti Bait CoIP	37207277
种属内	HCN1	O60741	PARP1	Homo sapiens	P09874	Anti Bait CoIP	37207277
种属内	HCN1	O60741	INA	Homo sapiens	Q16352	Anti Bait CoIP	37207277
种属内	HCN1	O60741	FMR1	Homo sapiens	Q06787	Anti Bait CoIP	37207277
种属内	HCN1	O60741	ARID3B	Homo sapiens	Q8IVW6	Anti Bait CoIP	37207277
种属内	HCN1	O60741	SRPK2	Homo sapiens	P78362	Anti Bait CoIP	37207277
种属内	HCN1	O60741	MARK3	Homo sapiens	P27448	Anti Bait CoIP	37207277
种属内	HCN1	O60741	C3	Homo sapiens	P01024	Anti Tag CoIP	33961781
种属内	HCN1	O60741	C3	Homo sapiens	P01024	Anti Bait CoIP	37207277

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 24

DEE24	Epileptic Encephalopathy, Early Infantile, 24
Eiee24	Developmental And Epileptic Encephalopathy, 24
Early Infantile Epileptic Encephalopathy 24	Encephalopathy, Epileptic, Early Infantile, Type 24

Generalized Epilepsy With Febrile Seizures Plus, Type 10

GEFSP10	Gefs+10
Gefs+, Type 10	Generalized Epilepsy With Febrile Seizures Plus 10
Generalised Epilepsy With Febrile Seizures Plus 10	Generalised Epilepsy With Febrile Seizures Plus Type 10
Generalized Epilepsy With Febrile Seizures Plus Type 10

Color Blindness

Color Vision Defect	Blindness Color
Colour Blindness	Colour Vision Deficiency
Color Vision Deficiency	Color Vision Defects
Defective Color Vision	Vision Defect, Color
Color-Vision Disease	Dyschromatopsia

Febrile Seizures

Febrile Seizure	Febrile Convulsions
Seizures Febrile

Ohtahara Syndrome

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Generalized Epilepsy With Febrile Seizures Plus

Gefs+	Genetic Epilepsy With Febrile Seizures Plus
Generalized Epilepsy With Febrile Seizures-Plus	Genetic Epilepsy With Febrile Seizures-Plus
Epilepsy, Generalized, With Febrile Seizures Plus

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-18940	Cilobradine		/	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13422	Zatebradine hydrochloride	Antagonist	99.06%	否
HY-13422A	Zatebradine	Antagonist	99.27%	否
HY-160505	RO-275	Inhibitor	≥99.0%	否
HY-163455	pan-HCN-IN-1	Inhibitor	/	否
HY-RS06046	HCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HCN1	VGNC	VGNC:102223
Macaca mulatta	HCN1	VGNC	VGNC:110459
Bos taurus	HCN1	VGNC	VGNC:29776
Canis familiaris	HCN1	VGNC	VGNC:41620
Rattus norvegicus	HCN1	RGD	RGD:620688
Mus musculus	HCN1	MGD	MGI:1096392

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HCN1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

关于 HCN1

功能概要

HCN1 基因产物(1)

HCN1 蛋白结构

HCN1 蛋白互作信息

关联疾病

直系同源

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HCN1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

关于 HCN1

功能概要

HCN1 基因产物(1)

HCN1 蛋白结构

HCN1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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