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  4. Cilobradine

Cilobradine (Cilo)是一种HCN通道阻滞剂，具有降低心率的活性。Cilobradine能够阻断人类HCN1、HCN2、HCN3和HCN4通道的慢内向电流。Cilobradine在小鼠窦房结细胞中对内源性If的阻断效率略高（IC50值为0.62μM）。Cilobradine可以使心率剂量依赖性地从600降至200 bpm，ED50值为1.2 mg/kg。Cilobradine在大于5 mg/kg时会诱发心律失常，其特征表现为T波与P波之间的周期性波动。

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Cilobradine Chemical Structure

Cilobradine Chemical Structure

CAS No. : 147541-45-5

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Cilobradine 的其他形式现货产品:

Other Forms of Cilobradine:

Cilobradine 相关抗体

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  • 生物活性

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生物活性

Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62μM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves[1].

分子量

482.61

Formula

C28H38N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cilobradine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Cilobradine147541-45-5CiloOthersInhibitorinhibitorinhibit

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目录号：
HY-18940
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