PYGB - glycogen phosphorylase B Gene

中文名称：糖原磷酸化酶 B

种属: Homo sapiens

同用名: GPBB

基因 ID: 5834 | 基因类型: protein coding

关于 PYGB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,248,085-25,298,012 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues and 2 paralogues. Broad expression in colon (RPKM 67.8), heart (RPKM 66.8) and 23 other tissues.

功能概要

由该基因编码的蛋白质是一种主要存在于大脑中的糖原磷酸化酶。编码的蛋白质形成同型二聚体，可以结合成同型四聚体，即糖原磷酸化酶的酶促活性形式。这种酶的活性受 AMP 的正向调节，受 ATP、ADP 和葡萄糖-6-磷酸的负向调节。该酶催化糖原降解中的决速步骤。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this Enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This Enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

PYGB 基因产物(1)

mRNA	Protein	Name
NM_002862.4	NP_002853.2	glycogen phosphorylase, brain form

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10638593	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PYGB 蛋白结构

Phosphorylase

0
200
400
600
843 a.a.

蛋白主名

其他名称

glycogen phosphorylase, brain form

phosphorylase, glycogen

PYGB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PYGB	P11216	PYGL	Homo sapiens	P06737	Y2H Array	25416956
种属内	PYGB	P11216	PYGL	Homo sapiens	P06737	Anti Tag CoIP	33961781
种属内	PYGB	P11216	PYGL	Homo sapiens	P06737	Y2H Prey Pooling	25416956
种属内	PYGB	P11216	PYGL	Homo sapiens	P06737	Validated Y2H	25416956
种属内	PYGB	P11216	FKBP5	Homo sapiens	Q13451	Crosslink	30021884
种属内	PYGB	P11216	PYGM	Homo sapiens	P11217	Anti Tag CoIP	33961781
种属内	PYGB	P11216	PYGM	Homo sapiens	P11217	Validated Y2H	32296183
种属内	PYGB	P11216	PYGM	Homo sapiens	P11217	Y2H Array	32296183
种属内	PYGB	P11216	PYGM	Homo sapiens	P11217	Y2H Prey Pooling	32296183
种属内	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Validated Y2H	32296183
种属内	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Anti Tag CoIP	33961781
种属内	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Y2H Array	32296183
种属内	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Y2H Prey Pooling	32296183
种属内	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
种属内	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
种属内	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Glycogen Storage Disease Vi

Glycogen Storage Disease Type Vi	Hers Disease
GSD6	Gsd Vi
Hepatic Glycogen Phosphorylase Deficiency	Phosphorylase Deficiency Glycogen-Storage Disease Of Liver
Hers' Disease	Glycogen Storage Disease Type 6
Glycogen Storage Disease 6	Gsd Type Vi
Glycogenosis Type Vi	Glycogen Storage Disease, Type Vi
Hepatophosphorylase Deficiency Glycogenosis	Liver Phosphorylase Deficiency Syndrome
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Gsd Due To Liver Glycogen Phosphorylase Deficiency
Gsd Type 6	Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency
Glycogenosis Type 6	Hepatic Phosphorylase Deficiency
Liver Glycogen Phosphorylase Deficiency	Her
Glycogen Storage Disease Vib	Gsd-Vi
Liver Phosphorylase Deficiency	Storage Disease, Glycogen, Type Vi

Glycogen Storage Disease Viii

Glycogen Storage Disease Type Viii	Glycogenosis Type Viii
Glycogen Storage Disease 8	Hepatic Glycogen Phosphorylase Kinase Deficiency
Glycogenosis Type 8	Hepatic Phosphorylase Kinase Deficiency
Pykl	Phosphorylase Kinase Deficiency Of Liver
Glycogen Storage Disease, Type Ix

Glycogen Storage Disease V

Mcardle Disease	Myophosphorylase Deficiency
Glycogen Storage Disease Type V	Muscle Glycogen Phosphorylase Deficiency
Pygm Deficiency	Gsd V
Glycogen Storage Disease, Type V	Glycogenosis Type V
Glycogen Storage Disease Type 5	GSD5
Pygmy	Mcardle'S Disease
Mcardle Type Glycogen Storage Disease	Gsd Type V
Pygmy, African	Gsdv
Gsd 5	Glycogenosis 5
Mcardle Syndrome	Muscle Phosphorylase Deficiency
Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency	Gsd Due To Muscle Glycogen Phosphorylase Deficiency
Gsd Type 5	Glycogenosis Due To Muscle Glycogen Phosphorylase Deficiency
Glycogenosis Type 5	Glycogen Storage Disease 5
Gsd-V	Mcardles Disease
Storage Disease, Glycogen, Type V

Glycogen Storage Disease Ixa

Glycogen Storage Disease Type 9a	Glycogen Storage Disease Type Ixa
Glycogenosis Type 9a	Glycogenosis Type Ixa
Gsd Type 9a	Gsd Type Ixa
Gsd9a

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Myoclonic Epilepsy Of Lafora

Lafora Disease	Epilepsy, Progressive Myoclonic 2b
EPM2	Melf
Epilepsy, Progressive Myoclonic 2a	Epm2a
Lafora'S Disease	Lafora Body Disease
Lbd	Epilepsy, Progressive Myoclonic, 2a
Lafora Progressive Myoclonic Epilepsy	Epilepsy Progressive Myoclonic 2
Lafora Body Disorder	Pme Type 2
Progressive Myoclonic Epilepsy Type 2	Progressive Myoclonus Epilepsy Type 2
Epilepsy, Progressive Myoclonic 2	Epm2b
Ld	Progressive Myoclonic Epilepsy 2
Progressive Myoclonic Epilepsy 2a	Progressive Myoclonic Epilepsy 2b
Progressive Myoclonic Epilepsy Lafora Type	Epilepsy, Myoclonic, Of Lafora

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11488	PYGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PYGB	MGD	MGI:97828
Rattus norvegicus	PYGB	RGD	RGD:3460
Felis catus	PYGB	VGNC	VGNC:69192
Bos taurus	PYGB	VGNC	VGNC:57019
Canis familiaris	PYGB	VGNC	VGNC:52899
Macaca mulatta	PYGB	VGNC	VGNC:76631

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PYGB - glycogen phosphorylase B Gene

关于 PYGB

功能概要

PYGB 基因产物(1)

PYGB 蛋白结构

PYGB 蛋白互作信息

关联疾病

直系同源

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PYGB - glycogen phosphorylase B Gene

关于 PYGB

功能概要

PYGB 基因产物(1)

PYGB 蛋白结构

PYGB 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z