1. Gene
  2. FKBP5 - FKBP prolyl isomerase 5 Gene

FKBP5 - FKBP prolyl isomerase 5 Gene

中文名称:FKBP 脯氨酰异构酶 5

种属: Homo sapiens

同用名: P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10

基因 ID: 2289 | 基因类型: protein coding

关于 FKBP5

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,573,590-35,728,583 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 97.5), lymph node (RPKM 33.3) and 18 other tissues.

功能概要

该基因编码的蛋白质是免疫亲和蛋白家族的成员,它在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。这种编码的蛋白质是一种顺反式脯氨酰异构酶,可与免疫抑制剂 FK506 和雷帕霉素结合。它被认为介导钙调神经磷酸酶抑制。它还与成熟的异源寡聚孕酮受体复合物以及 90 kDa 热休克蛋白和 P23 蛋白在功能上相互作用。已发现该基因具有多个聚腺苷酸化位点。可变剪接导致多个转录变体。[RefSeq 提供,2009 年 3 月]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate Calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric Progesterone Receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

FKBP5 基因产物(4)

mRNA Protein Name
NM_001145775.3 NP_001139247.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NM_001145776.2 NP_001139248.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NM_001145777.2 NP_001139249.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform 2
NM_004117.4 NP_004108.1 peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
9660753 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
11350175 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14676191 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
28147277 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chaperone-mediated protein folding IDA
IDA: 通过直接分析推断
11350175 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FKBP5 蛋白结构

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (44 - 135)

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (160 - 247)

TPR_11

TPR_11: TPR repeat (319 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase FKBP5

51 kDa FK506-binding protein

FKBP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FKBP5 Q13451 PYGB Homo sapiens P11216 35271311
种属内
FKBP5 Q13451 CDK9 Homo sapiens P50750 35271311
种属内
FKBP5 Q13451 CDK9 Homo sapiens P50750 25036637
种属内
FKBP5 Q13451 HSP90AA1 Homo sapiens P07900 29079741
种属内
FKBP5 Q13451 HSP90AA1 Homo sapiens P07900
DSC
29079741
种属内
FKBP5 Q13451 HSP90AA1 Homo sapiens P07900 35271311
种属内
FKBP5 Q13451 EGFR Homo sapiens P00533 25036637
种属内
FKBP5 Q13451 STK11 Homo sapiens Q15831 25036637
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 35271311
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238
NMR
30382094
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 21170051
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 25036637
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 30382094
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 30382094
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 30382094
种属内
FKBP5 Q13451 HSP90AB1 Homo sapiens P08238 30382094
种属内
FKBP5 Q13451 MCM7 Homo sapiens P33993 35271311
种属内
FKBP5 Q13451 MAPT Homo sapiens P10636-8 30382094
种属内
FKBP5 Q13451 MAPT Homo sapiens P10636-8
NMR
30382094
种属内
FKBP5 Q13451 MAPT Homo sapiens P10636-8 30382094
种属内
FKBP5 Q13451 MAPT Homo sapiens P10636-8 30382094
种属内
FKBP5 Q13451 MAPT Homo sapiens P10636-8 30382094
种属内
FKBP5 Q13451 KSR2 Homo sapiens Q6VAB6 25036637
种属内
FKBP5 Q13451 CHUK Homo sapiens O15111 14743216
种属内
FKBP5 Q13451 CHUK Homo sapiens O15111
TAP
14743216
种属内
FKBP5 Q13451 CHUK Homo sapiens O15111 33961781
种属内
FKBP5 Q13451 CHUK Homo sapiens O15111 35271311
种属内
FKBP5 Q13451 CHUK Homo sapiens O15111 25036637
种属内
FKBP5 Q13451 MCMBP Homo sapiens Q9BTE3-2 25036637
种属内
FKBP5 Q13451 MCMBP Homo sapiens Q9BTE3-2 32296183
种属间
FKBP5 Q13451 Q9WMX2-PRO_0000037552 Hepatitis C virus Q9WMX2-PRO_0000037552 24169621
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Borderline Personality Disorder
Acute Stress Disorder

Traumatic Stress Disorder

Stress Disorders, Traumatic, Acute

Stress Disorders, Traumatic

Myelofibrosis

Primary Myelofibrosis

Agnogenic Myeloid Metaplasia

Idiopathic Myelofibrosis

Myeloid Metaplasia

Myelofibrosis With Myeloid Metaplasia

Osteomyelofibrosis

Megakaryocytic Myelosclerosis

Myelosclerosis

Chronic Idiopathic Myelofibrosis

Myelofibrosis, Idiopathic

Myelofibrosis With Myeloid Metaplasia, Somatic

Myelofibrosis, Somatic

Aleukemic Myelosis

Bone Marrow Fibrosis

MYELOF

MMM

Agnogenic Myeloid Metaplasia With Myelofibrosis

Ammm

Myelosclerosis With Myeloid Metaplasia

Myelofibrosis Nos

Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness

Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]

Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction

Post-Traumatic Stress Disorder

PTSD

Traumatic Neurosis

Post Traumatic Stress Disorder

Stress Disorders, Post-Traumatic

Posttraumatic Stress Disorder

Ptsd - [Post Traumatic Stress Disorder]

Trauma-Related Disorders

Mental Depression

Depression

Depressive Disorder

Atypical Depressive Disorder

Atypical Depression

Dissociative Amnesia

Psychogenic Amnesia

Amnesia, Dissociative

Amnesia, Psychogenic

Amnesia Neurosis

Hysterical Fugue

Dissociative Fugue

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder

Phobia, Specific

Specific Phobia

Simple Phobia

Phobia, Simple

Isolated Phobia

Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Skin Atrophy

Atrophic Condition Of Skin

Atrophoderma

Atrophy - Skin

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FKBP5 MGD MGI:104670
Rattus norvegicus FKBP5 RGD RGD:1309155
Bos taurus FKBP5 VGNC VGNC:29024
Canis familiaris FKBP5 VGNC VGNC:40891
Macaca mulatta FKBP5 VGNC VGNC:72665
Felis catus FKBP5 VGNC VGNC:62281
Others FKBP5 NCBI