CDK9 - cyclin dependent kinase 9 Gene

中文名称：细胞周期蛋白依赖性激酶 9

种属: Homo sapiens

同用名: TAK; C-2k; CTK1; CDC2L4; PITALRE

基因 ID: 1025 | 基因类型: protein coding

关于 CDK9

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,786,034-127,790,792 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 26 paralogues. Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是细胞周期蛋白依赖性蛋白激酶 (CDK) 家族的成员。 CDK 家族成员与 S. cerevisiae cdc28 和 S. pombe cdc2 的基因产物高度相似，被称为重要的细胞周期调控因子。该激酶被发现是多蛋白复合物 TAK/P-TEFb 的一个组成部分，后者是 RNA 聚合酶 II 定向转录的延伸因子，通过磷酸化 RNA 聚合酶 II 最大亚基的 C 末端结构域发挥作用。该蛋白与其调节亚基细胞周期蛋白 T 或细胞周期蛋白 K 形成复合物并受其调节。发现 HIV-1 Tat 蛋白与该蛋白和细胞周期蛋白 T 相互作用，这表明该蛋白可能与艾滋病有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

CDK9 基因产物(1)

mRNA	Protein	Name
NM_001261.4	NP_001252.1	cyclin-dependent kinase 9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 7SK snRNA binding	IDA IDA: 通过直接分析推断	11713533	GOA
enables DNA binding	IDA IDA: 通过直接分析推断	16109376	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: 通过直接分析推断	9499409	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	12037670	GOA
enables kinase activity	IDA IDA: 通过直接分析推断	22959624	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9499409	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	14701750	GOA
enables transcription coactivator binding	IPI IPI: 通过物理相互作用推断	12037672	GOA
enables transcription elongation factor activity	IDA IDA: 通过直接分析推断	14580347	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to cytokine stimulus	IDA IDA: 通过直接分析推断	17956865	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: 通过直接分析推断	14701750	GOA
involved in nucleus localization	IDA IDA: 通过直接分析推断	12942536	GOA
involved in positive regulation by host of viral transcription	IDA IDA: 通过直接分析推断	10866664	GOA
involved in positive regulation of protein localization to chromatin	IDA IDA: 通过直接分析推断	29335245	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	29335245	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	9499409	GOA
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	16109376	GOA
involved in regulation of DNA repair	IDA IDA: 通过直接分析推断	20493174	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	20930849	GOA
involved in regulation of mRNA 3'-end processing	IMP IMP: 通过突变表型推断	19575011	GOA
NOT involved in regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	19575011	GOA
involved in regulation of muscle cell differentiation	IMP IMP: 通过突变表型推断	12037670	GOA
involved in replication fork processing	IDA IDA: 通过直接分析推断	20930849	GOA
involved in transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	28426094	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	14580347	GOA
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: 通过直接分析推断	19844166	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of P-TEFb complex	IDA IDA: 通过直接分析推断	18483487	GOA
located in PML body	IDA IDA: 通过直接分析推断	18250157	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: 通过直接分析推断	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: 通过物理相互作用推断	9499409	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	14701750	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9499409	GOA
part of transcription elongation factor complex	IDA IDA: 通过直接分析推断	22195968	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK9 蛋白结构

Pkinase

0
100
200
300
372 a.a.

蛋白主名

其他名称

cyclin-dependent kinase 9

CDC2-related kinase	cell division cycle 2-like protein kinase 4
cell division protein kinase 9	serine/threonine protein kinase PITALRE
tat-associated kinase complex catalytic subunit

关联疾病

疾病名称

别名

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6	Congenital Nongoitrous Hypothyroidism 6
Hypothyroidism, Congenital, Non-Goitrous, 6	Hypothyroidism, Congenital, Nongoitrous, Type 6

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Approval

生物活性分子 (3)

目录号	产品名	作用方式	纯度	是否罕见病
HY-16297A	Abemaciclib	Inhibitor	99.94%	是
HY-10492	Dinaciclib	Inhibitor	99.36%	是
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	是

Clinical Phase

生物活性分子 (22)

目录号	产品名	作用方式	纯度	Phase
HY-112088	AZD4573	Inhibitor	99.98%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.78%	Phase 2
HY-13914	Roniciclib	Inhibitor	98.09%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-16559	Riviciclib hydrochloride		98.89%	Phase 2
HY-103712B	Samuraciclib hydrochloride hydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-138293	SY-5609	Inhibitor	99.66%	Phase 1
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-137478A	KB-0742 dihydrochloride	Inhibitor	99.24%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.85%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 1

Pre-clinical Phase

生物活性分子 (105)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-103618	THZ531	Inhibitor	99.86%	否
HY-103248	Toyocamycin	Inhibitor	99.90%	否
HY-12214A	NVP-2	Inhibitor	99.60%	否
HY-103019	(+)-Enitociclib	Inhibitor	99.66%	否
HY-130665	TL12-186	Inhibitor	99.63%	否
HY-101257	YKL-5-124	Inhibitor	98.79%	否
HY-111388A	SEL120-34A monohydrochloride	Inhibitor	99.29%	否
HY-18340	(R)-CR8	Inhibitor	99.61%	否
HY-11009	CGP60474	Inhibitor	99.23%	否
HY-130709	PROTAC CDK2/9 Degrader-1	Inhibitor	99.85%	否
HY-123954	BTX-A51	Inhibitor	98.58%	否
HY-15878	LDC000067	Inhibitor	98.00%	否
HY-12445	Asnuciclib	Inhibitor	99.76%	否
HY-13461A	PHA-767491 hydrochloride	Inhibitor	98.06%	否
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	否
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	否
HY-112626	CDK12-IN-2	Inhibitor	99.36%	否
HY-X0150	JSH-150	Inhibitor	98.36%	否
HY-103628	PROTAC CDK9 Degrader-1	Inhibitor	98.03%	否
HY-144117	GFB-12811	Inhibitor	98.00%	否
HY-12280	THZ2	Inhibitor	99.03%	否
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	否
HY-12293	LY2857785	Inhibitor	99.92%	否
HY-119940	MC180295	Inhibitor	98.89%	否
HY-111388B	SEL120-34A hydrochloride	Inhibitor	99.98%	否
HY-13231	CDK9-IN-1	Inhibitor	98.52%	否
HY-16462	CDK9-IN-2	Inhibitor	99.37%	否
HY-143584	AZ5576	Inhibitor	99.88%	否
HY-103019B	(-)-Enitociclib	Inhibitor	99.69%	否
HY-101257B	YKL-5-124 TFA	Inhibitor	99.44%	否
HY-13033	CDK-IN-2	Inhibitor	98.97%	否
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	否
HY-18944	FIT-039	Inhibitor	99.56%	否
HY-103646	CK7	Inhibitor	99.72%	否
HY-15241	NVP-LCQ195	Inhibitor	98.81%	否
HY-12871	Atuveciclib Racemate	Inhibitor	98.48%	否
HY-126251	CDK9-IN-7	Inhibitor	98.05%	否
HY-102039	CDK9-IN-8	Inhibitor	99.65%	否
HY-139980	CDK9-IN-13	Inhibitor	99.22%	否
HY-153260	TP-1287	Inhibitor	95.10%	否
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	否
HY-100429	CAN508	Inhibitor	99.59%	否
HY-124639	CDK9 inhibitor HH1	Inhibitor	97.97%	否
HY-130852	CDK9-IN-11	Inhibitor	96.03%	否
HY-153556	GW297361	Inhibitor	98.13%	否
HY-100950	ABC1183	Inhibitor	99.19%	否
HY-X0009	JSH-009	Inhibitor	/	否
HY-139328	CDK12-IN-5	Inhibitor	99.01%	否
HY-111427	CDK8/19-IN-1	Inhibitor	98.03%	否
HY-162037	CDDD11-8	Inhibitor	99.62%	否
HY-130850	CDK9-IN-10	Inhibitor	98.00%	否
HY-115714	CDK9-IN-12	Inhibitor	99.65%	否
HY-12843	Bohemine	Inhibitor	98.93%	否
HY-143585	CDK9-IN-14	Inhibitor	99.91%	否
HY-13266	BS-181	Inhibitor	98.10%	否
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	否
HY-111388	SEL120-34A	Inhibitor	/	否
HY-139329	CDK12-IN-6	Inhibitor	98.09%	否
HY-14372	BS-194	Inhibitor	99.36%	否
HY-13461	PHA-767491	Inhibitor	99.85%	否
HY-151436	ZLMT-12	Inhibitor	/	否
HY-130001	CDK9-IN-9	Inhibitor	/	否
HY-130981	FN-1501-propionic acid		/	否
HY-110368	BS-181 dihydrochloride	Inhibitor	/	否
HY-131063	CDK6/9-IN-1	Inhibitor	/	否
HY-103712	Samuraciclib	Inhibitor	/	否
HY-169244	CDK-TCIP1	Inhibitor	/	否
HY-149963	PROTAC CDK9 degrader-6	Inhibitor	/	否
HY-161768	VCC972839:01	Inhibitor	/	否
HY-151898	CDK4/6-IN-14	Inhibitor	/	否
HY-145408	CDK7/9-IN-1	Inhibitor	/	否
HY-150573	CDK2-IN-12	Inhibitor	/	否
HY-155787	SHR5428	Inhibitor	/	否
HY-149870	PROTAC CDK9 degrader-8	Inhibitor	/	否
HY-168518	PROTAC CDK9 degrader-9	Degrader	/	否
HY-150641	CDK-IN-9	Inhibitor	/	否
HY-153426	CDK9-IN-23	Inhibitor	/	否
HY-139327	CDK12-IN-4	Inhibitor	/	否
HY-137478	KB-0742	Inhibitor	98.92%	否
HY-112811	PROTAC CDK9 degrader-2	Inhibitor	/	否
HY-151878	CDK7-IN-20	Inhibitor	/	否
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	否
HY-161463	CDK2-IN-28	Inhibitor	/	否
HY-123034	CDKI-83	Inhibitor	/	否
HY-157980	CDK9-IN-32	Inhibitor	/	否
HY-162706	BSJ-5-63	Degrader	/	否
HY-150562	CDK9-IN-19	Inhibitor	/	否
HY-149962	PROTAC CDK9 degrader-5	Inhibitor	/	否
HY-149495	CP-07	Degrader	/	否
HY-147771	ZLWT-37	Inhibitor	/	否
HY-151984	CDK9-IN-22	Inhibitor	/	否
HY-136841	SLM6	Inhibitor	/	否
HY-162619	CDK9-IN-33	Inhibitor	/	否
HY-156083	CDK9-IN-28	Inhibitor	/	否
HY-163856	CDK7-IN-30	Inhibitor	/	否
HY-156795	PROTAC CDK9/CycT1 Degrader-2	Inhibitor	/	否
HY-161379	CLZX-205	Inhibitor	/	否
HY-161595	CDK5-IN-4	Inhibitor	/	否
HY-155153	CDK9-IN-24	Inhibitor	/	否
HY-112450	Olomoucine II	Inhibitor	/	否
HY-164619	CDK9-IN-34	Inhibitor	/	否
HY-112403	(S)-Roscovitine	Inhibitor	/	否
HY-123826	CCT68127	Inhibitor	/	否
HY-119120	JTK-101	Inhibitor	/	否
HY-111356	IIIM-290	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CDK9	MGD	MGI:1328368
Macaca mulatta	CDK9	VGNC	VGNC:104886
Canis familiaris	CDK9	VGNC	VGNC:39062
Felis catus	CDK9	VGNC	VGNC:102911
Bos taurus	CDK9	VGNC	VGNC:27136
Rattus norvegicus	CDK9	RGD	RGD:1359638
Others	CDK9	NCBI

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