CCNT1 - cyclin T1 Gene

中文名称：细胞周期素 T1

种属: Homo sapiens

同用名: CCNT; CYCT1; HIVE1

基因 ID: 904 | 基因类型: protein coding

关于 CCNT1

Cytogenetic location: 12q13.11-q13.12 Genomic coordinates (GRCh38): 12:48,688,458-48,716,707 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 11.5), testis (RPKM 9.4) and 25 other tissues.

功能概要

该基因编码高度保守的细胞周期蛋白 C 亚家族的成员。编码的蛋白质与细胞周期蛋白依赖性激酶 9 紧密相关，并且是正转录延伸因子 b (p-TEFb) 的主要亚基。在人类中，存在多种形式的正转录延伸因子 b，其中可能包括几种不同的细胞周期蛋白中的一种以及细胞周期蛋白依赖性激酶 9。含有编码的细胞周期蛋白和细胞周期蛋白依赖性激酶 9 的复合物充当人类免疫缺陷病毒的辅助因子 1 型 (HIV-1) Tat 蛋白，对于病毒转录的完全激活既是必要的又是充分的。该细胞周期蛋白及其激酶伙伴还通过最大 RNA 聚合酶 II 亚基的羧基末端结构域的磷酸化参与触发转录物延伸。该基因的过度表达与肿瘤生长有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 4 月]

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CCNT1 基因产物(5)

mRNA	Protein	Name
NM_001240.4	NP_001231.2	cyclin-T1 isoform a
NM_001277842.2	NP_001264771.1	cyclin-T1 isoform b
NM_001413198.1	NP_001400127.1	cyclin-T1 isoform c
NM_001413199.1	NP_001400128.1	cyclin-T1 isoform d
NM_001413200.1	NP_001400129.1	cyclin-T1 isoform e

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 7SK snRNA binding	IDA IDA: 通过直接分析推断	11713533	GOA
enables DNA binding	IDA IDA: 通过直接分析推断	16109376	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	25116364	GOA
enables RNA polymerase binding	IPI IPI: 通过物理相互作用推断	15563843	GOA
enables cyclin-dependent protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	29849146	GOA
enables molecular condensate scaffold activity	IDA IDA: 通过直接分析推断	29849146	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9499409	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation by host of viral transcription	IDA IDA: 通过直接分析推断	10866664	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15563843	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	9499409	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of P-TEFb complex	IDA IDA: 通过直接分析推断	18483487	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: 通过直接分析推断	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: 通过物理相互作用推断	18566585	GOA
NOT located in nucleolus	IDA IDA: 通过直接分析推断	16109376	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	29849146	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12944466	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNT1 蛋白结构

Cyclin_N

0
200
400
600
726 a.a.

蛋白主名

其他名称

cyclin-T1

CDK9-associated C-type protein

CCNT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	X-Ray Diffraction	20535204
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Tag CoIP	26659056
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	CoIP	9491887
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	20562857
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	19387490
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Ion Exchange Chrom	20535204
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Tag CoIP	19387490
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	NMR	17724342
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	19387490
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	19387490
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	18483487
Intra	CCNT1	O60563	AFF4	Homo sapiens	Q9UHB7	Anti Tag CoIP	20153263
Cross	CCNT1	O60563	tat	Human immunodeficiency virus	P04608	Ion Exchange Chrom	20535204
Cross	CCNT1	O60563	tat	Human immunodeficiency virus	P04608	X-Ray Diffraction	20535204

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-122720	SEC inhibitor KL-1	Activator	99.38%	否
HY-123972	SEC inhibitor KL-2	Inhibitor	99.80%	否
HY-RS02141	CCNT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CCNT1	VGNC	VGNC:70735
Bos taurus	CCNT1	VGNC	VGNC:26978
Mus musculus	CCNT1	MGD	MGI:1328363
Rattus norvegicus	CCNT1	RGD	RGD:1311151
Canis familiaris	CCNT1	VGNC	VGNC:38906
Others	CCNT1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCNT1 - cyclin T1 Gene

关于 CCNT1

功能概要

CCNT1 基因产物(5)

CCNT1 蛋白结构

CCNT1 蛋白互作信息

关联疾病

直系同源

热门区域

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CCNT1 - cyclin T1 Gene

关于 CCNT1

功能概要

CCNT1 基因产物(5)

CCNT1 蛋白结构

CCNT1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z