HEXIM1 - HEXIM P-TEFb complex subunit 1 Gene

中文名称：HEXIM P-TEFb 复合亚基 1

种属: Homo sapiens

同用名: CLP1; EDG1; HIS1; MAQ1

基因 ID: 10614 | 基因类型: protein coding

关于 HEXIM1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,148,475-45,152,099 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 1 paralogue.

功能概要

该基因的表达由六亚甲基双乙酰胺在血管平滑肌细胞中诱导。该基因没有内含子。[RefSeq 提供，2008 年 7 月]

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

HEXIM1 基因产物(1)

mRNA	Protein	Name
NM_006460.3	NP_006451.1	protein HEXIM1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 7SK snRNA binding	IDA IDA: 通过直接分析推断	12832472	GOA
enables P-TEFb complex binding	IDA IDA: 通过直接分析推断	18249148	GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA IDA: 通过直接分析推断	14580347	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17724342	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12832472	GOA
enables protein kinase inhibitor activity	IDA IDA: 通过直接分析推断	28431135	GOA
enables snRNA binding	IDA IDA: 通过直接分析推断	14580347	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	14580347	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of innate immune response	IDA IDA: 通过直接分析推断	28712728	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18483487	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	14580347	GOA
involved in negative regulation of viral transcription	IMP IMP: 通过突变表型推断	18249148	GOA
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: 通过突变表型推断	22948151	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of 7SK snRNP	IDA IDA: 通过直接分析推断	18249148	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12581153	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12581153	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HEXIM1 蛋白结构

HEXIM

0
100
200
300
359 a.a.

蛋白主名

其他名称

protein HEXIM1

HMBA-inducible

HEXIM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	TAP	24981860
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Fluorescence Spectr	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	HEXIM1	O94992	TERF2	Homo sapiens	Q15554	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-163282	NB512	Inhibitor	/	否
HY-RS06145	HEXIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HEXIM1	VGNC	VGNC:62803
Macaca mulatta	HEXIM1	VGNC	VGNC:104615
Mus musculus	HEXIM1	MGD	MGI:2385923
Rattus norvegicus	HEXIM1	RGD	RGD:1559851
Bos taurus	HEXIM1	VGNC	VGNC:29826
Canis familiaris	HEXIM1	VGNC	VGNC:41670

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HEXIM1 - HEXIM P-TEFb complex subunit 1 Gene

关于 HEXIM1

功能概要

HEXIM1 基因产物(1)

HEXIM1 蛋白结构

HEXIM1 蛋白互作信息

关联疾病

直系同源

热门区域

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HEXIM1 - HEXIM P-TEFb complex subunit 1 Gene

关于 HEXIM1

功能概要

HEXIM1 基因产物(1)

HEXIM1 蛋白结构

HEXIM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z