2. Cell Cycle/DNA Damage Neuronal Signaling Apoptosis
  3. CDK Cholinesterase (ChE) Apoptosis
  4. ZLMT-12

ZLMT-12 (compound 35) 是他克宁衍生物，是一种有效的 CDK2/9 抑制剂，抑制 CDK9 和 CDK2 的 IC50 值分别为 0.002 和 0.011 μM。ZLMT-12 对 AChE (IC50=19.023 μM) 和 BuChE (IC50=2.768 μM) 有弱抑制作用。ZLMT-12 具有低毒和抗增殖活性。ZLMT-12 诱导细胞凋亡 (apoptosis)，阻滞细胞周期在 S 期和 G2/M 期。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ZLMT-12 Chemical Structure

ZLMT-12 Chemical Structure

CAS No. : 2841473-39-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ZLMT-12 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLMT-12 (compound 35), tacrine derivatives, is a potent, orally active CDK2/9 inhibitor with IC50 values of 0.002 and 0.011 μM for CDK9 and CDK2, respectively. ZLMT-12 has a weak inhibitory effect on AChE (IC50=19.023 μM) and BChE (IC50=2.768 μM). ZLMT-12 has low toxicity and antiproliferative activity. ZLMT-12 induces apoptosis and arrests the cell cycle in the S phase and G2/M phase[1].

IC50 & Target[1]

CDK9

0.002 μM (IC50)

CDK2

0.011 μM (IC50)

BChE

2.768 μM (IC50)

AChE

19.023 μM (IC50)

体外研究
(In Vitro)

ZLMT-12 (compound 35; 500 nM; 72 h) has antiproliferative activity in cancer cells[1].
ZLMT-12 (500 nM; 72 h) induces apoptosis and arrests the cell cycle in the S phase and G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZLMT-12 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116, SW480, A549, and MCF-7 cells
Concentration: 500 nM
Incubation Time: 72 hours
Result: Inhibited cell proliferative with GI50 values of 0.029, 0.328, 0.051, and 0.109 μM for HCT116, SW480, A549, and MCF-7 cells, respectively.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 10 and 20 nM
Incubation Time: 48 hours
Result: Increased apoptotic cells rate from 9.22% in the control to 23.77% at 10 nM and increased apoptotic cells rate to 46.2% at 20 nM.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 10 and 20 nM
Incubation Time: 48 hours
Result: Increased the percentage of the S phase from 31.43% to 42.75% (10 nM) and 49.38% (20 nM) respectively, and the percentage of the G2/M phase from 6.39% to 10.60% (10 nM) and 13.11% (20 nM), respectively.
体内研究
(In Vivo)

ZLMT-12 (compound 35; 10 mg/kg; p.o.; daily, for 21 d) has antitumor efficacy and inhibits tumor growth, without causing liver harm in the HCT116 xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/cA-nu mice with HCT116 xenografts (18-25 g, 6-8 weeks of age)[1]
Dosage: 10 mg/kg
Administration: Oral administration; daily, for 21 days
Result: Inhibited tumor growth with GI (tumor volume growth inhibition)=47.66% and TGI (tumor weight growth inhibition)=62.39%.
Exhibited no significant changes in behavior or body weight in mice.
Had no obvious liver injury.
Animal Model: Male Sprague-Dawley rats (240±20 g)[1]
Dosage: 2 mg/kg (i.v.) and 20 mg/kg (p.o.) (Pharmacokinetic Analysis)
Administration: Intravenous injection and oral administration; once
Result: 1.19
Parameter 2 mg/kg (i.v.) 20 mg/kg (p.o.)
T1/2 (h) 0.461 1.77
Tmax (h) 0.083/td> 1.00
Cmax (ng/mL) 206 67.8
AUCo-t (h*ng/mL) 110 302
AUCo-∞ (h*ng/mL) 115 316
CL (L/h/kg) 18.7
Vss(L/Kg) 12.6
F (%) 27.47
分子量

479.02

Formula

C26H31ClN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZLMT-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLMT-122841473-39-8ZLMT12ZLMT 12CDKCholinesterase (ChE)ApoptosisCyclin dependent kinasetacrine derivativeanticancerlow toxicityHCT116 cellscell cycleInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ZLMT-12
目录号：
HY-151436
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z