2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Hexokinase HSV Apoptosis
  4. 2-Deoxy-D-glucose

2-Deoxy-D-glucose  (Synonyms: 2-脱氧-D-葡萄糖; 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose)

目录号: HY-13966 纯度: 99.93%
COA 产品使用指南

摩尔计算器

2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。

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2-Deoxy-D-glucose Chemical Structure

2-Deoxy-D-glucose Chemical Structure

CAS No. : 154-17-6

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规格 价格 是否有货 数量
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g ￥1488
In-stock
10 g ￥2550
In-stock
50 g   询价  

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Customer Review

Other Forms of 2-Deoxy-D-glucose:

2-Deoxy-D-glucose 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 166 篇科研文献

WB

    2-Deoxy-D-glucose purchased from MCE. Usage Cited in: Ann N Y Acad Sci. 2023 Mar 18.  [Abstract]

    2-Deoxy-D-glucose (2-DG; 200 μM) reduces the protein levels of CASP11, cleaved-CASP11, NLRP3, GSDMD-FL, and GSDMD-NT, accompanied by effective inhibition of the markers involved in glycolysis, in OCCM-30 cells.

    2-Deoxy-D-glucose purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 4;8(27):44669-44681.  [Abstract]

    Effect of 2-DG treatment on BRSK2 and other components of AKT/mTOR signaling pathway. PANC-1 cells are treated with series concentrations of 2-DG for three hours before analysis.

    查看 HSV 亚型特异性产品:

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    HSV-1 HSV-2 HSV

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1].

    IC50 & Target[1]

    HSV-1

     

    体外研究
    (In Vitro)

    2-Deoxy-D-glucose (2-DG、4、8 或 16 mM) 以剂量和时间依赖性方式显著降低 MCF-7 细胞中的 ATP 水平，这与 2-DG 对细胞的作用相似生长。在暴露于 4、8 或 16 mM 2-Deoxy-D-glucose 1、3 或以剂量和时间依赖性方式持续 5 天[1]。2-DG 处理可增加磷酸戊糖途径 (PPP) 代谢物的水平，并增加 6-磷酸葡萄糖脱氢酶产生的 NADPH。NADPH 的增加和谷胱甘肽合成酶表达的上调导致 NB4 细胞中 2-DG 还原形式的谷胱甘肽增加[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    2-Deoxy-D-glucose 相关抗体:
    体内研究
    (In Vivo)

    2-Deoxy-D-glucose (0.03%，w/w) 导致最终体重降低 7%，这具有统计学意义，并延迟了可触及的乳腺癌的出现[1]。2-Deoxy-D-glucose (3 mmol/kg，iv) 在大鼠肌肉中以剂量依赖性方式降低[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    164.16

    Formula

    C6H12O5
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    2-脱氧-D-葡萄糖
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : ≥ 24 mg/mL (146.20 mM)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 6.0916 mL 30.4581 mL 60.9162 mL
    5 mM 1.2183 mL 6.0916 mL 12.1832 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 130 mg/mL (791.91 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.93%

    COA (286 KB) RP-HPLC (206 KB) 元素分析报告 (210 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    The effect of 2-DG on cell growth is determined by evaluating the number of adherent cells. Briefly, MCF-7 cells are plated at 3×104 cells per well in flat-bottomed 96-well plates in 100 μL of culture medium under the culture conditions. After 24 hours, cells are fed with fresh medium including 2-Deoxy-D-glucose at doses of 0, 4, 8, or 16 mM. At days 1, 3, and 5 after 2-Deoxy-D-glucose exposure, cells are fixed with 1% glutaraldehyde, replaced with PBS, and stored at 4°C. At the end of an experiment, all of the plates are stained with 0.02% aqueous crystal violet for 30 minutes and rinsed with deionized water. After redissolving the bound crystal violet in 70% ethanol, the absorbance is determined at 590 nm using a SPECTRA MAX PLUS Microplate Spectrophotometer System.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    At 21 days of age, rats are injected with 50 mg 1-methyl-1-nitrosourea per kilogram of body weight (i.p.). Rats are housed two per cage in solid-bottomed polycarbonate cages equipped with a food cup. Six days following carcinogen injection, all rats are randomized into one of three groups, 30 rats per group, and are fed ad libitum AIN-93G diet containing 0.0%, 0.02%, or 0.03% (w/w) 2-Deoxy-D-glucose (2-DG) for 5 weeks. Animal rooms are maintained at 22±1°C with 50% relative humidity and a 12-hour light/12-hour dark cycle. Rats are weighed thrice per week and are palpated for detection of mammary tumors twice per week starting from 19 days postcarcinogen.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    2-Deoxy-D-glucose 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.0916 mL 30.4581 mL 60.9162 mL 152.2904 mL
    5 mM 1.2183 mL 6.0916 mL 12.1832 mL 30.4581 mL
    10 mM 0.6092 mL 3.0458 mL 6.0916 mL 15.2290 mL
    15 mM 0.4061 mL 2.0305 mL 4.0611 mL 10.1527 mL
    20 mM 0.3046 mL 1.5229 mL 3.0458 mL 7.6145 mL
    25 mM 0.2437 mL 1.2183 mL 2.4366 mL 6.0916 mL
    30 mM 0.2031 mL 1.0153 mL 2.0305 mL 5.0763 mL
    40 mM 0.1523 mL 0.7615 mL 1.5229 mL 3.8073 mL
    50 mM 0.1218 mL 0.6092 mL 1.2183 mL 3.0458 mL
    60 mM 0.1015 mL 0.5076 mL 1.0153 mL 2.5382 mL
    80 mM 0.0761 mL 0.3807 mL 0.7615 mL 1.9036 mL
    100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5229 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2-Deoxy-D-glucose154-17-62-DG 2-Deoxy-D-arabino-hexose D-Arabino-2-deoxyhexose2-脱氧-D-葡萄糖HexokinaseHSVApoptosisHerpes simplex virusInhibitorinhibitorinhibit

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