1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Cholinesterase (ChE) Inhibitors

Cholinesterase (ChE) Inhibitors

AChE

BChE

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Cholinesterase (ChE) Inhibitors, Agonists, Antagonists, Activators & Chemicals
Product Name AChE BChE Purity
Donepezil Hydrochloride
AChE
  99.92%
Donepezil
AChE
  99.87%
TMPyP4 tosylate
AChE
  ≥98.0%
Galanthamine
AChE
  99.96%
AChE/BChE-IN-24
AChE, IC50: 16.38 μM
BChE, IC50: 10.44 μM
Rivastigmine
AChE
BChE
99.93%
α-NETA
AChE
  ≥98.0%
Garcinol
AChE
BChE
≥99.0%
Imperatorin
AChE
BChE
98.72%
Physostigmine salicylate
AChE
  99.37%
Scopoletin
AChE
  99.89%
(-)-Huperzine A
AChE
  99.74%
Linarin
AChE
  98.00%
Buntanetap
AChE
  99.71%
Epiberberine chloride
AChE
BChE
99.02%
Isoimperatorin
AChE
  99.61%
Rivastigmine tartrate
AChE
  99.03%
Pyridostigmine bromide
AChE
  99.93%
Tacrine
AChE, IC50: 109 nM
  99.91%
Sinapine
AChE
  99.96%
Tacrine hydrochloride
AChE
BChE
99.95%
Timosaponin AIII
AChE
  99.73%
Chlorpyrifos
AChE
  99.94%
Ethopropazine hydrochloride
AChE
BChE
99.66%
Jatrorrhizine chloride
AChE
  99.88%
Corydaline
AChE
  99.70%
Sinapine thiocyanate
AChE
  99.74%
Itopride hydrochloride
AChE
  99.85%
Nodakenin
AChE
  98.76%
Tacrine hydrochloride (hydrate)
AChE
BChE
99.98%
Pralidoxime chloride
AChE
  99.73%
Galanthamine hydrobromide
AChE
  99.93%
Rhodiosin
AChE
  99.36%
Cyanidin-3-O-galactoside chloride
AChE
  99.20%
Coumaran
AChE
  99.54%
Acephate
AChE
  ≥98.0%
(-)-Carvone
eel AChE, Ki: 2.19 mM
  99.91%
N-p-trans-Coumaroyltyramine
AChE
  98.78%
Rhodionin
AChE
  98.78%
Tenuifolin
AChE
  99.24%
RPR121056
AChE
  99.59%
Phenserine
AChE
  99.55%
Physostigmine hemisulfate
AChE
  ≥99.0%
Pralidoxime iodide
AChE
  ≥98.0%
(±)-Huperzine A
AChE
  98.73%
β-NETA
AChE
  ≥98.0%
Benactyzine hydrochloride  
BChE, Ki: 0.01 mM
99.02%
Drofenine hydrochloride  
BChE
98.10%
Mca-YVADAP-Lys(Dnp)-OH TFA
AChE
  98.85%
Fenchlorphos
AChE
  99.87%
Ladostigil hydrochloride
AChE, IC50: 31.8 μM
  99.94%
Pirimiphos-methyl
AChE
  98.00%
Galanthaminone
AChE
  99.63%
Acotiamide monohydrochloride trihydrate
AChE
  99.49%
PE154
AChE, IC50: 280 pM
BChE, IC50: 16 nM
99.01%
BChE-IN-17
eel AChE, IC50: 686.4 μM
hBCHE, IC50: 32.5 nM
eqBCHE, IC50: 10.5 nM
99.07%
Violanthin
AChE
 
Manghaslin
AChE
  ≥98.0%
Zanapezil fumarate
AChE
  99.63%
Ebeiedinone
AChE
BChE
99.51%
Pirimicarb
AChE
  99.50%
Anatoxin-a
AChE
 
Territrem B
AChE
 
Zanapezil
AChE
  99.63%
Isorosmanol
AChE
  98.08%
Polygalacic acid
AChE
  98.92%
P11149
AChE
  99.23%
SD-6
hAChE, IC50: 0.907 μM
hBCHE, IC50: 1.579 μM
≥98.0%
Sophoflavescenol
AChE
BChE
98.15%
AChE/BChE-IN-10
AChE, IC50: 0.176 μM
BChE, IC50: 0.47 μM
99.67%
Galanthamine N-Oxide
AChE
BChE
99.90%
Pitofenone hydrochloride
AChE
  99.88%
(±)-Marmesin
AChE
 
Epiberberine
AChE
BChE
98.46%
Y13g dihydrochloride
AChE
  99.89%
ASS234
AChE, IC50: 350 nM
BChE, IC50: 460 nM
99.6%
Swertianolin
AChE
  99.54%
Dihydrowithaferin A
AChE
  ≥99.0%
PCS1055
hAChE, IC50: 120 nM
  98.02%
Z32439948  
BChE, IC50: 1.4 μM ([1])
HDAC6-IN-5
AChE, IC50: 0.72 μM
 
ZLMT-12
AChE, IC50: 19.023 μM
BChE, IC50: 2.768 μM
AChE/BChE-IN-1
AChE
BChE
AChE/BChE-IN-11
AChE, IC50: 70 μM
BChE, IC50: 71 μM
AChE-IN-46
AChE
 
Bis-(-)-8-demethylmaritidine
AChE
 
Carbonic anhydrase/AChE-IN-1
AChE, Ki: 5.07 nM
 
BChE-IN-38
AChE, Ki: 14.09 nM
BChE, Ki: 1.15 nM
tau/Aβ40 aggregation-IN-1
hAChE, IC50: 16.10 μM
equine serum BChE, IC50: 0.96 μM
Artanin
AChE, IC50: 51 μM
 
BChE-IN-22  
eqBCHE, IC50: 0.53 μM
hCAI/II-IN-8
AChE, IC50: 46.27 ±0.7 nM
BChE, IC50: 43.38 ± 0. nM
AChE-IN-77
AChE, IC50: 29.46 μM
 
Z164597606  
hBCHE, IC50: 1.7 μM
eqBCHE, IC50: 1.3 μM
KBR 2822
AChE
 
Multitarget AD inhibitor-2
AChE, IC50: 0.14 μM
BChE, IC50: 11.6 μM
hAChE/hBACE-1-IN-1
hBACE-1, IC50: 0.23 μM
hAChE, IC50: 0.076 μM
hBCHE, IC50: 1.204 μM
AChE-IN-60
AChE, IC50: 27 nM
BChE, IC50: 43 nM
BChE-IN-28
AChE, IC50: 3691 nM
BChE, IC50: 8 nM
BChE, Ki: 12.16 nM
hCA I-IN-4
AChE, Ki: 21.21 nM
BChE, Ki: 7.65 nM
AChE-IN-22
AChE
 
BChE-IN-35  
BChE
hAChE/hBuChE/GSK-3β-IN-1
hAChE, IC50: 28.88 nM
hBCHE, IC50: 131.90 nM
eeAChE-IN-3
RatAChE, IC50: 0.49 μM
EeAChE, IC50: 0.54 μM
RatBuChE, IC50: 8.54 μM
BChE-IN-31
AChE, IC50: 5.9 μM
BChE, IC50: 65 nM
H3R antagonist 4
hAChE, IC50: 9.73 μM
EeAChE, IC50: 7.04 μM
eqBCHE, IC50: 13.40 ~ 88 μM
hBChE-IN-2  
hBCHE, IC50: 0.67 μM
AChE/MAO-B-IN-3
hAChE, IC50: 0.0257 μM
 
Dual AChE-MAO B-IN-3
EeAChE, IC50: 0.58 ± 0.0 μM
 
Methyl ganoderate A acetonide
AChE
 
AChE/MAO-B-IN-4
AChE
 
AChE/BChE-IN-3 hydrochloride
AChE
BChE
Desoxypeganine
AChE, IC50: 17 μM
BChE, IC50: 2 μM
AChE-IN-75
AChE
 
CL-13  
BChE, IC50: 1.15 μM
AChE-IN-21
EeAChE, IC50: 2.66 nM
RatBuChE, IC50: 19.10 μM
AChE/BChE-IN-25
hAChE, IC50: 7.9 nM
eqBCHE, IC50: 0.79 nM
BChE-IN-10  
BChE, IC50: 6.4 μM
Kokusaginine
AChE, IC50: 28.2 μM
 
AChE-IN-17
AChE
 
AChE-IN-10
AChE
 
AChE-IN-59
AChE, IC50: 0.05 μM
BChE, IC50: 4.68 μM
Bisnorcymserine  
BChE, IC50: 0.228 nM
BChE-IN-34  
eqBCHE, IC50: 25 nM
BChE/MAO-B-IN-1  
BChE, IC50: 375 nM
BChE-IN-5
AChE
BChE
AChE-IN-5
AChE
 
AChE/BChE-IN-23
hAChE, IC50: 0.91 μM
hBCHE, IC50: 1.02 μM
eqBCHE, IC50: 1.19 μM
AChE/BChE-IN-19
AChE, IC50: 21.45 nM
BChE, IC50: 18.42 nM
hAChE-IN-3
AChE, IC50: 0.44 μM
BChE, IC50: 0.08 μM
Fmoc-L-Val-OH-13C5,15N
AChE
  ≥98%
AChE/BChE-IN-6
hAChE, IC50: 2.248 μM
hBCHE, IC50: 0.809 μM
AChE-IN-35
AChE, IC50: 5.88 μM
 
AChE/BChE/MAO-B-IN-2
AChE, IC50: 83.9 nM
BChE, IC50: 31.2 nM
Broussonin A  
BChE, IC50: 4.16 μM
BuChE-IN-7  
hBCHE, IC50: 40 nM
eqBCHE, IC50: 80 nM
AChE-IN-64
AChE, IC50: 36.9 μM
 
hAChE-IN-10
hAChE, IC50: 6.34 nM
 
Manumycin B
AChE, IC50: 15 mM
 
Xanthohumol I
AChE
BChE
AChE/MAO-IN-1
hAChE, IC50: 0.0248 μM
 
Pitofenone
AChE
 
AChE-IN-34
AChE, IC50: 3.98 μM
AChE, Ki: 0.044 μM
 
Monarsen
AChE
 
AChE/BChE-IN-18
AChE, IC50: 0.315 μM
 
Pralidoxime
AChE
 
MAO-B-IN-7
hAChE, IC50: 41 nM
 
Isogarcinol
AChE, IC50: 1.13 ± 0.0 μM
BChE, IC50: 8.30 ± 0.0 μM
α-Amylase/α-Glucosidase-IN-7
AChE, IC50: 9.25 μM
BChE, IC50: 10.06 μM
S16–1029  
hBCHE, IC50: 48.1 nM
eqBCHE, IC50: 11.35 nM
BChE-IN-26
AChE, Ki: 35 μM
BChE, Ki: 1.6 μM
S21-1011  
hBCHE, IC50: 0.162 μM
eqBCHE, IC50: 0.059 μM
AChE-IN-52
AChE
 
AChE-IN-4
AChE, IC50: 24.1 μM
 
AChE/hCA I-IN-1
AChE, IC50: 302.2 nM
 
AChE-IN-63
hAChE, IC50: 0.103 μM
hBCHE, IC50: 10 μM
hBChE-IN-1
hAChE, IC50: 7.84 ± 0.8 μM
EeAChE, IC50: 0.18 μM
hBCHE, IC50: 0.0070 ± 0 μM
equine serum BChE, IC50: 0.088 μM
AChE-IN-24
AChE
 
Stemoninine
hAChE, IC50: 5.52 μM
 
AChE-IN-8
AChE
 
Isoprocarb-d3
AChE
 
eeAChE-IN-2
AChE
 
AChE/BuChE/MAO-B-IN-2
AChE, IC50: 5.3 μM
BChE, IC50: 12.4 μM
ChE/Aβ1-42-IN-1
AChE
 
K203
AChE
 
AChE-IN-72
AChE, IC50: 0.59 μM
BChE, IC50: 5.02 μM
hBChE-IN-3
AChE, IC50: 7.4 nM
BChE, IC50: 1.9 nM
CEase-IN-1
AChE, IC50: 45.9 μM
 
AChE-IN-68
hAChE, IC50: 0.040 ± 0. μM
hBCHE, IC50: >1000 μM
AChE-IN-9
AChE, IC50: 0.4 μM
 
BChE-IN-11  
BChE, IC50: 2.1 ± 0.3 μM
Velnacrine
AChE, IC50: 3.27 μM
 
BChE-IN-12  
BChE, IC50: 2.3 μM
hAChE-IN-8
hAChE, IC50: 0.486 μM
hBCHE, IC50: 0.542 μM
Protriptyline
AChE, IC50: 0.06 mM
 
AChE/PDE4-IN-1
AChE, IC50: 0.28 μM
 
AChE/BuChE-IN-3
AChE, IC50: 0.65 μM
BChE, IC50: 5.77 μM
hAChE/hBACE-1-IN-2
hBACE-1, IC50: 0.38 μM
hAChE, IC50: 0.113 μM
hBCHE, IC50: 1.48 μM
BChE-IN-39
AChE, IC50: 3.98 μM
BChE, IC50: 0.08 μM
MR2938
AChE, IC50: 5.04 ± 0.7 μM
BChE, IC50: >20 μM
AChE-IN-47
AChE
 
BChE-IN-36
EeAChE, IC50: 72.1 nM
eqBCHE, IC50: 4.2 nM
AChE/BChE-IN-16
hAChE, IC50: 30 nM
hBCHE, IC50: 48 nM
BuChE-IN-11  
hBCHE, IC50: 0.44 μM
(Rac)-Sclerone
AChE, IC50: 192.65 ± 1 μg/mL
 
Azamethiphos
AChE
 
BChE-IN-19  
BChE, IC50: 0.04 μM
hAChE/hBACE-1-IN-4
hAChE, IC50: 0.283 μM
hBCHE, IC50: 0.231 μM
AChE/BuChE-IN-6
AChE, IC50: 1.24 μg/mL
BChE, IC50: 1.85 μg/mL
AChE/BChE-IN-17
AChE, IC50: 125.06 ± 2 nM
BChE, IC50: 119.68 ± 2 nM
BuChE-IN-12  
BChE, IC50: 0.52 nM
AChE-IN-11
AChE
 
AChE-IN-44
AChE
 
BChE-IN-15
hAChE, IC50: 558.6 nM
hBCHE, IC50: 1.76 nM
K1833
hAChE, IC50: 58 μM
hBCHE, IC50: 0.57 μM
AChE-IN-28
AChE, IC50: 0.2 nM
 
Blestrin D  
BChE, IC50: 8.1 μM
hAChE-IN-6
hAChE, IC50: 0.16 μM
hBCHE, IC50: 0.69 μM
AChE/Aβ-IN-4
AChE, IC50: 1.72 ± 0.1 μM
 
AChE/Aβ-IN-3
AChE, IC50: 1.29 μM
 
eeAChE-IN-1
AChE
 
hAChE/Aβ1-42-IN-1
AChE
 
MAO-A/B-IN-3
AChE, IC50: 1370 nM
 
Itopride
AChE
 
AChE/BChE/MAO-B-IN-3
hAChE, IC50: 0.0473 μM
hBCHE, IC50: 0.0782 μM
BChE-IN-29
AChE, IC50: 0.74 μM
BChE, IC50: 0.075 μM
K027
AChE
BChE
BChE-IN-32  
hBCHE, IC50: 0.109 μM
α-Glucosidase-IN-68
AChE, IC50: 0.774 μM
BChE, IC50: 0.793 μM
AChE/BChE-IN-12
EeAChE, IC50: 2.57 ± 0.3 μM
eqBCHE, IC50: 3.26 ± 0.1 μM
AChE-IN-51
AChE, IC50: 84 nM
BChE, IC50: 97 nM
AChE/BACE1/GSK3β-IN-1
AChE, IC50: 1 μM
 
NDs-IN-1
hAChE
hBCHE
hAChE-IN-9
hAChE, IC50: 0.05 μM
hBCHE, IC50: 2.85 μM
AChE-IN-19
AChE
 
AChE-IN-20
AChE, IC50: 397.32 nM
AChE, Ki: 335.76 nM
 
AChE/BChE-IN-20
AChE, IC50: 34.81 μM
BChE, IC50: 20.66 μM
AChE-IN-69
AChE, IC50: 1.67 μM
 
SBN-284
hAChE, IC50: 0.31 μM
EeAChE, IC50: 0.37 μM
eqBCHE, IC50: 0.29 μM
Kuwanon U
AChE, IC50: 19.69 μM
AChE, IC50: 6.48 μM
BChE, Ki: 10.11 μM
BChE, Ki: 9.59 μM
Isograndifoliol
AChE, IC50: 342.9 μM
BChE, IC50: 0.9 μM
BChE-IN-33  
BChE, IC50: 14.78 nM
MR33317
AChE, IC50: 41 nM
 
Desoxypeganine hydrochloride
AChE, IC50: 17 μM
BChE, IC50: 2 μM
AChE/CA I-IN-1
AChE, Ki: 1.85 μM
 
AChE/BuChE/MAO-B-IN-1
hAChE, IC50: 4.8 μM
hBCHE, IC50: 13.7 μM
Methylene Violet 3RAX
AChE, Ki: 1.58 μM
BChE, Ki: 0.51 μM
Memoquin
hAChE, IC50: 1.55 nM
 
AChE-IN-67
AChE, IC50: 0.033±0.00 μM
BChE, IC50: >100 μM
AChE-IN-55
EeAChE, IC50: 4.8 μM
 
Lycodoline  
BChE, IC50: 667 μM
Dual AChE-MAO B-IN-4
AChE, IC50: 261 nM
 
TRV-7019  
BChE
99.64%
hAChE-IN-2
hAChE, IC50: 0.71 μM
 
BChE-IN-16  
hBCHE, IC50: 3.8 nM
AChE-IN-56
AChE
 
AChE/MAO-IN-2
AChE, IC50: 0.0224 μM
 
Y13g
AChE
 
AChE/BuChE-IN-5
AChE, IC50: 46.9 nM
RatBuChE, IC50: 3.5 nM
hAChE-IN-1
hAChE, IC50: 1.09 μM
 
ChEs/MAOs-IN-2
AChE, IC50: 0.30 μM
BChE, IC50: 0.40 μM
Flucopride
AChE, IC50: 24 nM
 
SB-1436
EeAChE, IC50: 0.176 μM
EeAChE, Ki: 0.046 μM
eqBCHE, IC50: 0.37 μM
eqBCHE, Ki: 0.115 μM
WAY-361789
AChE
 
AL284
AChE
 
7-Methoxytacrine
hAChE, IC50: 10.5 μM
hBCHE, IC50: 21 μM
Benactyzine  
BChE, Ki: 0.01 mM
1,2-Didehydrotanshinone IIA  
BChE, IC50: 5.98 μM
T14-A24
AChE, Ki: 22 nM
 
Lucidadiol
AChE, IC50: 31.03 μM
BChE, IC50: 156.27 μM
Buxbodine B
AChE, IC50: 50 μM
 
MHP 133
AChE, Ki: 69 μM
 
p-Xylene bis(pyridinium bromide)
hAChE, IC50: 1540 μM
BChE, IC50: 529 μM
Donepezil N-oxide
AChE
 
TAE-1
AChE