2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. AChE/BuChE/MAO-B-IN-2

AChE/BuChE/MAO-B-IN-2 (compound 4b) 是一种具有 AChE/BuChE 抑制作用的药物，其靶向 AChE，BuChE，huMAO-B 的 IC50 值分别为 5.3 μM，12.4 μM，1.9 μM，在体外具有良好的血脑屏障通透性，可穿过血脑屏障 (BBB)。AChE/BuChE/MAO-B-IN-2 (compound 4b) 对阿尔茨海默氏病 (AD) 脑内过量的 AChE/BuChE 具有抑制作用，可用于抗阿尔茨海默氏病 (AD) 的研究。

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AChE/BuChE/MAO-B-IN-2 Chemical Structure

AChE/BuChE/MAO-B-IN-2 Chemical Structure

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AChE/BuChE/MAO-B-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research[1].

IC50 & Target

AChE

5.3 μM (IC50)

BChE

12.4 μM (IC50)

hMAO-B

1.9 μM (IC50)

体外研究
(In Vitro)

AChE/BuChE/MAO-B-IN-2 (compound 4b) (5, 10, 20 μmol/L, 2 h) 对Aβ1-42诱导的PC12 细胞损伤具有显著的神经保护作用[1]。
AChE/BuChE/MAO-B-IN-2 (1 mg/mL for incubate, 0, 0.5, 1、 1.5, 2, 3 h) 在人工胃肠液、血浆和大鼠肝微粒体中具有良好和稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BuChE/MAO-B-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12 cell
Concentration: 5, 10, 20 μmol/L
Incubation Time: 2 h
Result: Increased the cell viability to 70.9 %, 75.0 % (p < 0.05) and 79.7 % (p < 0.01), respectively, in a dose-dependent manner.
体内研究
(In Vivo)

AChE/BuChE/MAO-B-IN-2 (compound 4b) (0.0049, 0.0195 and 0.078 μg/mL for treated, 10min) 能显著改善ACAL3诱导的斑马鱼 AD 模型的运动障碍和反应能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AlCl3-induced zebrafish AD[1]
Dosage: 0.0049, 0.0195 and 0.078 μg/mL
Administration: incubation
Result: Presented the best distance velocity with 0.0195 μg/mL under the dark condition, with 0.0049 μg/mL under the light condition and with 0.0195 μg/mL under the alternating dark light.
分子量

327.35

Formula

C19H18FNO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BuChE/MAO-B-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE/MAO-B-IN-2Cholinesterase (ChE)Monoamine OxidaseMAOAlzheimer’s diseasemultifunctional chelatorssite-activated prochelatorzebrafish AD modelInhibitorinhibitorinhibit

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