2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BChE-IN-16

BChE-IN-16 (compound 87) 是一种高效的 BChE 抑制剂，对hBChE的IC50 值为3.8 nM。BChE-IN-16 具有低细胞毒性、潜在的 CNS 渗透性以及独特的适应性，可用于阿尔兹海默症 (AD) 的研究。

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BChE-IN-16 Chemical Structure

BChE-IN-16 Chemical Structure

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BChE-IN-16 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC50 of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research.

IC50 & Target

hBCHE

3.8 nM (IC50)

体外研究
(In Vitro)

BChE-IN-16在IC50值大于10 μM时，对hAChE的抑制率为零[1]。
BChE-IN-16对hBChE竞争性抑制，Ki 值为 4.04 nM[1]。
BChE-IN-16对SH-SY5Y 细胞系具有细胞毒性，IC50 值为87.0 μM[1]。
BChE-IN-16对HepG2 细胞系具有细胞毒性，IC50 值为76.0 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BChE-IN-16 相关抗体:
分子量

433.56

Formula

C28H32FNO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE-IN-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-16Cholinesterase (ChE)Alzheimer's diseaseBChEhAChE SH-SY5Y cellsHepG2 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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