2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE/BuChE-IN-5

AChE/BuChE-IN-5 (compound 5a) 是一种双靶点抑制剂。AChE/BuChE-IN-5 对乙酰胆碱酯酶 (AChE) (IC50=46.9 nM) 和丁基胆碱酯酶 (BuChE) (IC50=3.5 nM) 具有良好的纳摩尔抑制活性。AChE/BuChE-IN-5 可用于阿尔茨海默病的研究。

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AChE/BuChE-IN-5 Chemical Structure

AChE/BuChE-IN-5 Chemical Structure

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AChE/BuChE-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=3.5 nM). AChE/BuChE-IN-5 can be used for Alzheimer's Disease research[1].

IC50 & Target[1]

AChE

46.9 nM (IC50)

RatBuChE

3.5 nM (IC50)

体外研究
(In Vitro)

AChE/BuChE-IN-5 可抑制乙酰胆碱酯酶 (AChE) (IC50=46.9 nM) 和丁基胆碱酯酶 (BuChE) (IC50=46.9 nM)，其抑制效果优于已知的双抑制剂利 Rivastigmine 在 AD 病动物模型中(HY-17368)[1]。
AChE/BuChE-IN-5 对 BuChE 的选择性高于 AChE，选择性指数 (SI) 为 0.07，表明其对 BuChE 的抑制作用更强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BuChE-IN-5 相关抗体:
体内研究
(In Vivo)

AChE/BuChE-IN-5(1 mg/kg，ip.；14 天) 具有神经保护，抗氧化和抗凋亡作用在 AD 动物模型中[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reduced MDA levels, elevated GSH levels, β-amyloid protein levels and 8- OHdG levels on an animal model of rats pre-treated with lead acetate.
Reduced the expression level of caspase-3 and VEGF compared with the PbAc group.
分子量

314.34

Formula

C19H14N4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BuChE-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE-IN-5Cholinesterase (ChE)AChE/BuChE inhibitoranimal model of rats pre-treated with lead acetateAlzheimer's DiseaseInhibitorinhibitorinhibit

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