2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-28

AChE-IN-28 (Compound 2h) 是一种选择性的乙酰胆碱酯酶 (acetylcholinesterase) 慢结合抑制剂，IC50 为 0.2 nM。

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AChE-IN-28 Chemical Structure

AChE-IN-28 Chemical Structure

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AChE-IN-28 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC50 of 0.2 nM[1].

IC50 & Target[1]

AChE

0.2 nM (IC50)

体内研究
(In Vivo)

AChE-IN-28 (Compound 2h) (0.005-0.1 mg/kg; i.p.; single dose) 改善大鼠重症肌无力症状。AChE-IN-28 在小鼠中的 LD50 为 10 mg/kg (i.p.)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats, experimental autoimmune model of myasthenia gravis (EAMG)[1]
Dosage: 0.005, 0.01, 0.015 and 0.1 mg/kg
Administration: Intraperitoneal injection, single dose
Result: The dose that restored the value of decrement of amplitude of APs in animals with EAMG to the level of control rats was 0.01 mg/kg. Showed a long lasting effect and had no significant effect on the force of urinary bladder contractions in animals with EAMG.
分子量

715.66

Formula

C33H48BrF3N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-28Cholinesterase (ChE)Wistar ratsmyasthenia gravisEAMGInhibitorinhibitorinhibit

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产品名称：
AChE-IN-28
目录号：
HY-151927
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