2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. Protriptyline

Protriptyline 是一种有效的抗抑郁剂 (antidepressant)。Protriptyline 抑制乙酰胆碱酯酶活性，IC50 值为 0.06 mM，并抑制 Aβ 自组装。Protriptyline 可用于研究抑郁症和阿尔茨海默病。

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Protriptyline Chemical Structure

Protriptyline Chemical Structure

CAS No. : 438-60-8

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Protriptyline 的其他形式现货产品:

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Protriptyline 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease[1][2][3].

IC50 & Target[1]

AChE

0.06 mM (IC50)

体外研究
(In Vitro)

Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Protriptyline 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: PC3 cells
Concentration: 50, 60 and 70 μM
Incubation Time: 24 hours
Result: Decreased cell viability in a concentration-dependent manner.
体内研究
(In Vivo)

Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of AD[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; for 21 days.
Result: Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.
Clinical Trial
分子量

263.38

Formula

C19H21N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Protriptyline 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protriptyline438-60-8Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaalzheimersAβ Self-AssemblyAChEInhibitorinhibitorinhibit

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