2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β Beta-secretase
  4. AChE-IN-63

AChE-IN-63 是 hAChE，hBChE，hBACE-1 的抑制剂 (IC50=0.103 μM (hAChE)，10 μM (hBChE) 和 1.342 μM (hBACE-1))。AChE-IN-63 抑制 Aβ 聚集，防止 Aβ1-42 的形成和沉积。AChE-IN-63 能有效穿透血脑屏障，具有口服有效性。AChE-IN-63 主要用于阿尔茨海默病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AChE-IN-63 Chemical Structure

AChE-IN-63 Chemical Structure

CAS No. : 876685-78-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AChE-IN-63 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].

IC50 & Target[1]

hAChE

0.103 μM (IC50)

hBCHE

10 μM (IC50)

体外研究
(In Vitro)

AChE-IN-63 (5-20 μM; 48 h) 以浓度依赖性的抑制 Aβ1-42 的聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-63 相关抗体:
体内研究
(In Vivo)

AChE-IN-63 (p.o.; 100 mg/kg; 单剂量) 在瑞士白化小鼠中没有表现出任何毒性或异常反应[1]。
AChE-IN-63 (p.o.; 5-20 mg/kg; 单剂量) 在东莨菪碱 (HY-N0296) Y 迷宫模型中改善了认知功能障碍小鼠的学习和记忆能力，展现了良好的抗氧化性性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine Y-Maze Model [1]
Dosage: 5; 10 ;20 mg/kg
Administration: p.o.; single dose
Result: Showed significant improvement in spontaneous alternation behavior.
Reduced AChE and MDA levels and increased CAT levels.
分子量

321.38

Formula

C18H19N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-63 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-63876685-78-8Cholinesterase (ChE)Amyloid-βBeta-secretaseβ-amyloid peptideAβAbetaBACEβ-SecretaseAlzheimer's DiseaseAnti-Aβ AggregationAntioxidantSwiss Albino MiceY-Maze TestInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AChE-IN-63
目录号：
HY-158261
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z