2. Neuronal Signaling Anti-infection
  3. Cholinesterase (ChE) Parasite
  4. Isogarcinol

Isogarcinol  (Synonyms: Cambogin)

目录号: HY-127087
产品使用指南

摩尔计算器

Isogarcinol (Cambogin) 是一种有效的 AChE 和 BChE 抑制剂，IC50 值分别为 1.13 和 8.30 μM。Isogarcinol 还具有杀利什曼原虫活性，对 L. donovani 的 IC50 为 0.33 μM。

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Isogarcinol Chemical Structure

Isogarcinol Chemical Structure

CAS No. : 71117-97-0

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规格 价格 是否有货 数量
1 mg ￥2700
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

Isogarcinol 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani[1].

IC50 & Target

AChE

1.13 ± 0.0 μM (IC50)

BChE

8.30 ± 0.0 μM (IC50)

Leishmania

0.33 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
19.21 μM
Compound: 1
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30500683]
HEL IC50
9.24 μM
Compound: 1
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
[PMID: 30500683]
HeLa IC50
16.46 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 30500683]
HepG2 IC50
7.3 μM
Compound: 9
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 24960143]
K562 IC50
14.1 μM
Compound: 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30500683]
L02 IC50
9.3 μM
Compound: 9
Cytotoxicity against human HL7702 cells by MTT assay
Cytotoxicity against human HL7702 cells by MTT assay
[PMID: 24960143]
MCF7 IC50
10.24 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30500683]
MCF7 IC50
4.8 μM
Compound: 9
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 24960143]
MDA-MB-231 IC50
5.7 μM
Compound: 9
Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
[PMID: 24960143]
U-251 IC50
2.8 μM
Compound: 8
Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
[PMID: 28729053]
分子量

602.80

Formula

C38H50O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isogarcinol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isogarcinol71117-97-0CamboginCholinesterase (ChE)ParasiteInhibitorinhibitorinhibit

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