2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. 7-Methoxytacrine

7-Methoxytacrine  (Synonyms: 7-MEOTA)

目录号: HY-W049312
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7-Methoxytacrine (7-MEOTA) 是一种人乙酰胆碱酯酶 (hAChE) 抑制剂，IC50 值为 10 μM，可以用于阿尔兹海默症 (AD) 的研究。

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7-Methoxytacrine Chemical Structure

7-Methoxytacrine Chemical Structure

CAS No. : 5778-80-3

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规格 价格 是否有货 数量
1 mg ￥2450
1 - 2 周
5 mg ￥5460
1 - 2 周
10 mg 现货 1 - 2 周
50 mg   询价  
100 mg   询价  

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7-Methoxytacrine 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD)[1].

IC50 & Target

hAChE

10.5 μM (IC50)

hBCHE

21 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
63 μM
Compound: 7-MEOTA; 1
Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 30851693]
HepG2 IC50
11.5 μM
Compound: 2; 7-MEOTA
Hepatotoxicity in human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
Hepatotoxicity in human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
[PMID: 26503905]
HepG2 IC50
120 μM
Compound: 7-MEOTA; 1
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 30851693]
HepG2 IC50
44.37 μM
Compound: 7-MEOTA
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 33984470]
HepG2 IC50
44.37 μM
Compound: 7-MEOTA
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29533874]
分子量

228.29

Formula

C14H16N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Methoxytacrine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Methoxytacrine5778-80-37-MEOTACholinesterase (ChE)Alzheimer’s disease (AD)Inhibitorinhibitorinhibit

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