2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-9

AChE-IN-9 是一种 Tacrine (HY-111338) 连接乙酰化 β-葡萄糖的糖缀合物。AChE-IN-9 也是一种 AChE 抑制剂，IC50 为 0.4 μM，对健康细胞的肝毒性低。Tacrine 可用于阿兹海默症的研究。

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AChE-IN-9 Chemical Structure

AChE-IN-9 Chemical Structure

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AChE-IN-9 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-9 is a Tacrine (HY-111338) glycoconjugate tethered with acetylated β-Glucose. AChE-IN-9 is also an AChE inhibitor with an IC50 value of 0.4 μM, with lower hepatotoxicity on healthy cells. Tacrine is used in Alzheimer's research[1].

IC50 & Target

AChE

0.4 μM (IC50)

体外研究
(In Vitro)

Tacrine (HY-111338) is mainly metabolized by CYP 1A2, but its glycoconjugates have shown more affinity towards CYP 3A4 rather than CYP 1A2[1].
AChE-IN-9 (compound A-1) (200 μM; 24 h) is non-toxic on HePG2 cell line with 100% cell viability, and shows lower hepatotoxicity than Tacrine (HY-111338) on healthy HepG2 cells[1].
AChE-IN-9 (10 μM; 24 h) inhibits AChE activity with inhibition rate of 96.6%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-9 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 cells
Concentration: 3.125, 6.25, 25, 50, 100, 200 μM
Incubation Time: 24 hours
Result: Showed much lower toxic effect on HepG2 cell than Tacrine (HY-111338) in a dose dependent manner, showing the inflexion point at the concentration of 100 µM.
分子量

609.63

Formula

C30H35N5O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-9Cholinesterase (ChE)hepatotoxicitytacrine glycoconjugatesβ-GlucoseAlzheimer'sacetylateInhibitorinhibitorinhibit

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产品名称：
AChE-IN-9
目录号：
HY-143291
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