2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BuChE-IN-11

BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 μM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing β-amyloid (Aβ) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimer's disease.

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BuChE-IN-11 Chemical Structure

BuChE-IN-11 Chemical Structure

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BuChE-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BuChE-IN-11 (Compound 3b-1) 是一种 BuChE 选择性抑制剂，其中hBuChE 的 IC50 为0.44 μM。PARP7-IN-22血脑屏障透过性高，具有自由基清除作用因此具有强大的抗氧化活性。BuChE-IN-11可以与胆碱结合位点、乙酰结合位点和外周阴离子位点相互作用，表现出亚微摩尔级别的BuChE抑制活性并且防止β-淀粉样蛋白 (Aβ) 的自聚集。BuChE-IN-11有望用于阿尔兹海默疾病领域研究[1]。
IC50 & Target[1]

hBCHE

0.44 μM (IC50)

eqBCHE

 

体外研究
(In Vitro)

BuChE-IN-11 (Compound 3b-1) (0.1-1 µM, 120 min) 具有极强抗氧化活性[1]。
BuChE-IN-11 (20 μM, 48h)具有抑制 αβ1-42 聚集的作用[1]。
低于25 μM的BuChE-IN-11 (12.5-100 μM for PC12, 25-100 μM for AML12, 24h) 对PC12和AML12细胞没有显著毒性[1]。
BuChE-IN-11 (18h) 显示出良好的血脑屏障渗透性 (CNS+)，可以穿过血脑屏障[1]。
BuChE-IN-11 被预测具有高胃肠道吸收活性和低心脏毒性风险[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BuChE-IN-11 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: PC12 and AML12 cells
Concentration: 12.5-100 μM for PC12, 25-100 μM for AML12
Incubation Time: 24 h
Result: Only exhibited significant cytotoxicity at concentrations greater than 25 µM. At concentrations below 25 µM, BuChE-IN-11 shows no significant cytotoxicity against PC12 and AML12 cells.
分子量

470.54

Formula

C28H27FN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BuChE-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BuChE-IN-11Cholinesterase (ChE)PC12 and AML12 cellsAntioxidant activityAlzheimer's diseaseInhibitorinhibitorinhibit

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