2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Pralidoxime

Pralidoxime  (Synonyms: 解磷定)

目录号: HY-B1738
产品使用指南

摩尔计算器

Pralidoxime 是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂。Pralidoxime 通过肟部分对结合神经毒剂磷中心的亲核攻击，重新激活受神经毒剂抑制的 AChE。Pralidoxime 是一种有机磷中毒的解毒剂。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Pralidoxime chloride 和 Pralidoxime iodide 通常具有更好的水溶性和稳定性。

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Pralidoxime Chemical Structure

Pralidoxime Chemical Structure

CAS No. : 6735-59-7

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Pralidoxime 的其他形式现货产品:

Customer Review

Other Forms of Pralidoxime:

Pralidoxime 相关抗体

Top Publications Citing Use of Products

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].

IC50 & Target

AChE

 

体内研究
(In Vivo)

Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: F1B6D2 mice (male, administered subcutaneously diethylparaoxon)[3]
Dosage: 10, 50, 100, and 150 mg/kg
Administration: Intramuscular administration, once
Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Clinical Trial
分子量

137.16

Formula

C7H9N2O+
CAS 号
中文名称

解磷定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pralidoxime 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pralidoxime6735-59-7解磷定Cholinesterase (ChE)reactivatordiethylparaoxonpralidoximeplethymosgraphyorganophosphatesnerve agentorganophosphorusInhibitorinhibitorinhibit

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