2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. BChE/MAO-B-IN-1

BChE/MAO-B-IN-1 是一种 BChE/MAO-B 双重抑制剂，IC50 值分别为 375 nM 和 20 nM。BChE/MAO-B-IN-1 可以抵抗 H2O2 和 6-OHDA 在 SH-SY5Y 细胞中诱导的氧化损伤，并在模拟血脑屏障的细胞模型中能够穿透中枢神经系统。BChE/MAO-B-IN-1 可用于阿尔茨海默病 (AD) 等神经系统疾病研究。

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BChE/MAO-B-IN-1 Chemical Structure

BChE/MAO-B-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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BChE/MAO-B-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE/MAO-B-IN-1 (compound 7) is a dual BChE/MAO-B inhibitor with IC50 values ​​of 375 nM and 20 nM, respectively. BChE/MAO-B-IN-1 protects against oxidative damage induced by H2O2 and 6-OHDA in SH-SY5Y cells. BChE/MAO-B-IN-1 can penetrate the central nervous system in a cell model that mimics the blood-brain barrier. BChE/MAO-B-IN-1 can be used in the study of neurological diseases such as Alzheimer's disease (AD)[1].

IC50 & Target

BChE

375 nM (IC50)

MAO-B

20 nM (IC50)

分子量

435.54

Formula

C25H25NO4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE/MAO-B-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE/MAO-B-IN-1Cholinesterase (ChE)Monoamine OxidaseMAOAcetylcholinesteraseBioisostereButyrylcholinesteraseMonoamine oxidasesMultitarget Structure-basedInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-158696
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