2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. AChE/BChE-IN-6

AChE/BChE-IN-6 (compound 22) 是一种有效的双重 AChE/BChE 抑制剂，对于 hBChE, hAChE 和 hMAO-B，其IC50 值分别为 0.809 µM、2.248 µM 和 > 100 µM。AChE/BChE-IN-6 能够穿透血脑屏障 (BBB)。AChE/BChE-IN-6 可用于阿尔茨海默病 (AD) 的研究。

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AChE/BChE-IN-6 Chemical Structure

AChE/BChE-IN-6 Chemical Structure

CAS No. : 2416910-94-4

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AChE/BChE-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

hMAO-B

＞ 100 μM (IC50)

hAChE

2.248 μM (IC50)

hBCHE

0.809 μM (IC50)

体外研究
(In Vitro)

AChE/BChE-IN-6 (compound 22) (1-100 µM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-6 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y and HepG2 cells
Concentration: 1-100 µM
Incubation Time: 48 hours
Result: Had non-cytotoxic at 20 µM on SH-SY5Y cells and at 50 µM on HepG2 cells.
分子量

366.50

Formula

C23H30N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-6 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-62416910-94-4Cholinesterase (ChE)Monoamine OxidaseMAOhBChEhAChEhMAO-Bblood-brain barrierAlzheimer’s diseaseSH-SY5YHepG2Inhibitorinhibitorinhibit

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