2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Amyloid-β Cholinesterase (ChE) MMP
  4. AChE-IN-51

AChE-IN-51 (compound 8C) 是一种口服有效的 AChE 和 BChE 非竞争性抑制剂 (IC50: 84 nM，97 nM)，还抑制 MMP-2 和淀粉样蛋白 Aβ1-42 聚集 (IC50: 724 nM，302 nM)。AChE-IN-51 的细胞毒性低，具有计算机预测的血脑屏障透过性。可用于阿尔茨海默病 (AD) 等疾病的研究。

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AChE-IN-51 Chemical Structure

AChE-IN-51 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

AChE-IN-51 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE (IC50: 84 nM, 97 nM). It also inhibits MMP-2 and amyloid Aβ1-42 aggregates (IC50: 724 nM, 302 nM). AChE-IN-51 has low cytotoxicity and in silico predicted blood-brain barrier permeability. Can be used for research on diseases such as Alzheimer's disease (AD)[1].

IC50 & Target[1]

AChE

84 nM (IC50)

BChE

97 nM (IC50)

MMP-2

724 nM (IC50)

分子量

344.39

Formula

C23H21OP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-51 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-51Amyloid-βCholinesterase (ChE)MMPβ-amyloid peptideAβAbetaMatrix metalloproteinasesAlzheimer's diseaseTriphenylphosphoranylideneacetylcholinesterasesilaneβ-amyloidInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-157382
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