2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE)
  4. ASS234

ASS234 是一种有效的单氨基氧化酶 (MAO) 抑制剂，对 MAO-A 和 MAO-B 的 IC50 值分别为 5.2 nM 和 43 nM。ASS234 还抑制 AChE 和 BuChE，IC50 分别为 350 nM 和 460 nM。

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ASS234 Chemical Structure

ASS234 Chemical Structure

CAS No. : 1334106-34-1

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规格 价格 是否有货 数量
5 mg ￥2462
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Customer Review

ASS234 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC50s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC50s of 350 nM and 460 nM, respectively[1].

IC50 & Target[1]

MAO-A

5.2 nM (IC50)

MAO-B

43 nM (IC50)

AChE

350 nM (IC50)

BChE

460 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.38 μM
Compound: 5
Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method
Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method
[PMID: 22023459]
HEK293 IC50
3.3 μM
Compound: II, ASS234
Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 mins
Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 mins
[PMID: 25418133]
HEK293 IC50
3.4 μM
Compound: II, ASS234
Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins
Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins
[PMID: 25418133]
分子量

443.62

Formula

C29H37N3O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.6%

COA (280 KB)

产品使用指南 (1538 KB)
参考文献

ASS234 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASS2341334106-34-1ASS 234ASS-234Monoamine OxidaseCholinesterase (ChE)MAOMAO-AMAO-BAChEBuChEInhibitorinhibitorinhibit

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目录号：
HY-121072
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