2. Neuronal Signaling Apoptosis Cell Cycle/DNA Damage Cytoskeleton
  3. Cholinesterase (ChE) Apoptosis Microtubule/Tubulin
  4. Kokusaginine

Kokusaginine 一种呋喃喹啉生物碱，对乙酰胆碱酯酶 (AChE) 具有抑制活性，IC50 为 28.2 μM。 Kokusaginine 抑制 MCF-7/ADR 细胞增殖并且诱导其凋亡 (apoptosis)。

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Kokusaginine Chemical Structure

Kokusaginine Chemical Structure

CAS No. : 484-08-2

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Kokusaginine 相关抗体

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].

IC50 & Target

AChE

28.2 μM (IC50)

体外研究
(In Vitro)

Kokusaginine (0-30 μM) 通过抑制微管蛋白聚合，抑制细胞 MCF-7、MDA-MB-231 及其多重耐药亚系 MCF-7/ADR、MDA-MB-231/ADR 的增殖，IC50 分别为 7.23，4.62，9.01 和 10.19 μM[2]。
Kokusaginine (6-24 μM) 剂量依赖性的诱导细胞 MCF-7 及其多重耐药亚系 MCF-7/ADR 凋亡 (apoptosis)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kokusaginine 相关抗体:

Apoptosis Analysis[2]

Cell Line: MCF-7 and MCF-7/ADR
Concentration: 0-24 μM
Incubation Time:
Result: Induced apoptosis.

Real Time qPCR[2]

Cell Line: MCF-7 and MCF-7/ADR
Concentration: 0-24 μM
Incubation Time:
Result: Decreased mRNA levels of P-gp in cells MCF-7/ADR.
分子量

259.26

Formula

C14H13NO4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kokusaginine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kokusaginine484-08-2Cholinesterase (ChE)ApoptosisMicrotubule/TubulinMCF-7MDA-MB-231breast cancerneurodegenerative diseasesInhibitorinhibitorinhibit

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