2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK9-IN-28

CDK9-IN-28 (化合物 10) 是一种有效的 CDK9 抑制剂。CDK9-IN-28 可作 PROTAC 靶蛋白配体，用于 PROTAC 合成。CDK9-IN-28 在实体瘤中显示出强大的抗增殖活性。

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CDK9-IN-28 Chemical Structure

CDK9-IN-28 Chemical Structure

CAS No. : 3020773-81-0

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CDK9-IN-28 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC CDK9/CycT1 Degrader-1 (compounds 10) is a potent inhibitor of CDK9. PROTAC CDK9/CycT1 Degrader-1 can be used as a PROTAC target protein ligand for PROTAC synthesis. PROTAC CDK9/CycT1 Degrader-1 shows strong anti-proliferative activity in solid tumors[1].

IC50 & Target

CDK9/cyclinT1

 

体外研究
(In Vitro)

CDK9-IN-28 在 U-2932 细胞中表现出明显的 CDK9 降解，在肿瘤中具有明显的抗增殖活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK9-IN-28 相关抗体:

Western Blot Analysis[1]

Cell Line: U-2932 cells
Concentration: 100nM
Incubation Time: 6h
Result: CDK9 degradation induced apoptosis, and degradation through autophagy.
体内研究
(In Vivo)

CDK9-IN-28 (5 mg/kg，腹腔注射，每天一次持续15天)在 MV4-11 肿瘤裸鼠模型中抑制了肿瘤生长[1]。 CDK9-IN-28 (1 mg/kg，静脉注射，5 mg/kg，腹腔注射)在 ICR (CD-1) 小鼠模型中显示出可接受的半衰期(T1/2:4.66h)和中等的生物利用度(F=43.1%)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MV4-11 tumor nude mice
Dosage: 5 mg/kg
Administration: Intraperitoneal injection, once a day for 15 days.
Result: Effective delayed of tumor growth but weight did not lose.
分子量

640.81

Formula

C32H40N4O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK9-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-283020773-81-0CDKCyclin dependent kinaseU-2932 cellsNude mice modelIntracellular pathogenic proteinsInhibitorinhibitorinhibit

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目录号：
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